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Structural characterization by x-ray methods of novel antimicrobialgallium-doped phosphate-based glasses

机译:新型抗微生物镓掺杂磷酸盐基玻璃的X射线方法结构表征

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Antimicrobial gallium-doped phosphate-based glasses of general composition (P205)0.45(CaO)0.16(Na20)0.39_x(Ga203)x (where x=0, 0.01, 0.03, and 0.05) have been studied using the advancedsynchrotron-based techniques of Ga K-edge x-ray absorption spectroscopy and high-energy x-raydiffraction to provide a structural insight into their unique properties. The results show that the Ga3+ions are octahedrally coordinated. Furthermore, substitution of Na20 by Ga203 strengthens thephosphate network structure because the presence of GaO6 octahedra inhibits the migration of theremaining Na+ ions. The results are discussed in terms of the use of Na20–CaO–P205 glasses ascontrolled-delivery devices for antimicrobial Ga3÷ ions in biomedical applications. We are therebyable to relate the atomic-scale environment of the Ga3+ ions beneficially to the glass dissolution, andthus to their ability to disrupt bacterial cell activity by usurping the role of iron.
机译:已使用先进的同步加速器技术研究了一般成分为(P205)0.45(CaO)0.16(Na20)0.39_x(Ga203)x(其中x = 0、0.01、0.03和0.05)的抗菌镓掺杂磷酸盐基玻璃Ga K边缘X射线吸收光谱法和高能X射线衍射技术的应用,以提供对其独特性质的结构见解。结果表明,Ga3 +离子是八面体配位的。此外,由于GaO 6八面体的存在抑制了剩余的Na +离子的迁移,所以用Ga 2 O 3取代Na 2 O增强了磷酸盐网络结构。讨论了在生物医学应用中使用Na20–CaO–P205玻璃作为抗菌性Ga3÷离子的受控输送装置的结果。因此,我们可以将Ga3 +离子的原子尺度环境与玻璃溶解有益地联系起来,从而与它们通过篡夺铁的作用破坏细菌细胞活性的能力有关。

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