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Unique magnetic signatures of mismatched base pairs in DNA

机译:DNA中错配碱基对的独特磁性特征

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Magnetic properties of DNA containing mispairs, such as different conformations of the G Amispair, or a G T mispair inserted into the DNA chain, have been theoretically investigated. Theessential ingredients for these studies, the charge transfer integrals, were evaluated from the DNAsequences containing the mispair and optimized in the solvent. We find that the magneticsusceptibilities of the host DNA chain containing a large number of Watson–Crick base pairs aresignificantly altered in the presence of the mispairs, and the effects depend on the choice of mispairs.In particular, insertion of even a single G A mispair changes the nature of magnetization (sign ofthe susceptibility) of the host DNA. We propose that measurement of the magnetic properties ofDNA might provide a direct route to detection and identification of those mispairs
机译:从理论上研究了含错配的DNA的磁性,例如不同构型的G Amispair或插入到DNA链中的G T错配。从包含错配的DNA序列中评估了这些研究的基本成分,即电荷转移积分,并在溶剂中对其进行了优化。我们发现包含大量沃森-克里克碱基对的宿主DNA链的磁化率在存在错配对的情况下发生了显着变化,其影响取决于错配对的选择。特别是,即使插入单个GA错配对也会发生变化。宿主DNA的磁化性质(磁化率的标志)。我们建议对DNA磁性的测量可能为检测和鉴定这些错配提供直接途径

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