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首页> 外文期刊>The Journal of Chemical Physics >Fluctuating bottleneck model studies on kinetics of DNA escape from alpha-hemolysin nanopores
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Fluctuating bottleneck model studies on kinetics of DNA escape from alpha-hemolysin nanopores

机译：从α-溶血素纳米孔中逃逸的动力学的波动瓶颈模型研究

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We have proposed a fluctuation bottleneck (FB) model to investigate the non-exponential kinetics of DNA escape from nanometer-scale pores. The basic idea is that the escape rate is proportional to the fluctuating cross-sectional area of DNA escape channel, the radius r of which undergoes a subdiffusion dynamics subjected to fractional Gaussian noise with power-law memory kernel. Such a FB model facilitates us to obtain the analytical result of the averaged survival probability as a function of time, which can be directly compared to experimental results. Particularly, we have applied our theory to address the escape kinetics of DNA through alpha-hemolysin nanopores. We find that our theoretical framework can reproduce the experimental results very well in the whole time range with quite reasonable estimation for the intrinsic parameters of the kinetics processes. We believe that FB model has caught some key features regarding the long time kinetics of DNA escape through a nanopore and it might provide a sound starting point to study much wider problems involving anomalous dynamics in confined fluctuating channels. (C) 2015 AIP Publishing LLC.
机译：我们提出了一个波动瓶颈（FB）模型，以研究DNA从纳米级孔中逸出的非指数动力学。基本思想是逃逸率与DNA逃逸通道的横截面积波动成正比，DNA逃逸通道的半径r经受具有幂律存储核的分数次高斯噪声的二次扩散动力学。这种FB模型有助于我们获得平均生存概率随时间变化的分析结果，可以将其与实验结果直接进行比较。特别地，我们已经应用我们的理论来解决DNA通过α-溶血素纳米孔的逃逸动力学。我们发现我们的理论框架可以在整个时间范围内很好地再现实验结果，并且可以合理地估算动力学过程的内在参数。我们认为，FB模型已经捕获了有关DNA通过纳米孔逃逸的长时间动力学的一些关键特征，它可能为研究涉及有限波动通道中异常动力学的更广泛问题提供了一个良好的起点。 （C）2015 AIP Publishing LLC。

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