...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Immunology: Official Journal of the American Association of Immunologists >Cutting edge: basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3, but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3.
【24h】

Cutting edge: basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3, but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3.

机译：前沿：在通过IL-3进行蠕虫感染期间，嗜碱性粒细胞被短暂地募集到引流淋巴结中，但是感染诱导的Th2免疫可以在没有嗜碱性粒细胞淋巴结募集或IL-3的情况下发展。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Basophils are recognized as immune modulators through their ability to produce IL-4, a key cytokine required for Th2 immunity. It has also recently been reported that basophils are transiently recruited into the draining lymph node (LN) after allergen immunization and that the recruited basophils promote the differentiation of naive CD4 T cells into Th2 effector cells. Using IL-3(-/-) and IL-3Rbeta(-/-) mice, we report in this study that the IL-3/IL-3R system is absolutely required to recruit circulating basophils into the draining LN following helminth infection. Unexpectedly, the absence of IL-3 or of basophil LN recruitment played little role in helminth-induced Th2 immune responses. Moreover, basophil depletion in infected mice did not diminish the development of IL-4-producing CD4 T cells. Our results reveal a previously unknown role of IL-3 in recruiting basophils to the LN and demonstrate that basophils are not necessarily associated with the development of Th2 immunity during parasite infection.
机译：嗜碱性粒细胞通过产生IL-4（Th2免疫所需的关键细胞因子）的能力而被公认为是免疫调节剂。最近还报道了，在过敏原免疫后，嗜碱性粒细胞被短暂地募集到引流淋巴结（LN）中，并且所募集的嗜碱性粒细胞促进了幼稚CD4T细胞向Th2效应细胞的分化。使用IL-3（-/-）和IL-3Rbeta（-/-）小鼠，我们在这项研究中报告说，在蠕虫感染后，绝对需要IL-3 / IL-3R系统才能将循环中的嗜碱性粒细胞募集到引流的LN中。出乎意料的是，IL-3或嗜碱性粒细胞LN的缺乏在蠕虫诱导的Th2免疫反应中起着很小的作用。此外，感染小鼠的嗜碱性粒细胞耗竭并不能减少产生IL-4的CD4 T细胞的发育。我们的研究结果揭示了IL-3在将嗜碱性粒细胞招募到LN方面的未知作用，并证明了在寄生虫感染期间嗜碱性粒细胞不一定与Th2免疫力的发展有关。

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号