...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Immunology: Official Journal of the American Association of Immunologists >The Integrins Mac-1 and {alpha}4{beta}1 Perform Crucial Roles in Neutrophil and T Cell Recruitment to Lungs during Streptococcus pneumoniae Infection.
【24h】

The Integrins Mac-1 and {alpha}4{beta}1 Perform Crucial Roles in Neutrophil and T Cell Recruitment to Lungs during Streptococcus pneumoniae Infection.

机译：整合素Mac-1和α4{beta} 1在肺炎链球菌感染期间在嗜中性粒细胞和T细胞对肺的募集中起关键作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Neutrophils and T cells play an important role in host protection against pulmonary infection caused by Streptococcus pneumoniae. However, the role of the integrins in recruitment of these cells to infected lungs is not well understood. In this study we used the twin approaches of mAb blockade and gene-deficient mice to investigate the relative impact of specific integrins on cellular recruitment and bacterial loads following pneumococcal infection. We find that both Mac-1 (CD11b/CD18) and alpha(4)beta(1) (CD49d/CD29) integrins, but surprisingly not LFA-1 (CD11a/CD18), contribute to two aspects of the response. In terms of recruitment from the circulation into lungs, neutrophils depend on Mac-1 and alpha(4)beta(1), whereas the T cells are entirely dependent on alpha(4)beta(1). Second, immunohistochemistry results indicate that adhesion also plays a role within infected lung tissue itself. There is widespread expression of ICAM-1 within lung tissue. Use of ICAM-1(-/-) mice revealed that neutrophils make use of this Mac-1 ligand, not for lung entry or for migration within lung tissue, but for combating the pneumococcal infection. In contrast to ICAM-1, there is restricted and constitutive expression of the alpha(4)beta(1) ligand, VCAM-1, on the bronchioles, allowing direct access of the leukocytes to the airways via this integrin at an early stage of pneumococcal infection. Therefore, integrins Mac-1 and alpha(4)beta(1) have a pivotal role in prevention of pneumococcal outgrowth during disease both in regulating neutrophil and T cell recruitment into infected lungs and by influencing their behavior within the lung tissue itself.
机译：中性粒细胞和T细胞在宿主防御肺炎链球菌引起的肺部感染中起重要作用。但是，整合素在将这些细胞募集到受感染的肺中的作用尚不清楚。在这项研究中，我们使用mAb阻断和基因缺陷小鼠的双重方法研究了特定整合素对肺炎球菌感染后细胞募集和细菌载量的相对影响。我们发现，Mac-1（CD11b / CD18）和alpha（4）beta（1）（CD49d / CD29）整合素都令人惊讶，但LFA-1（CD11a / CD18）却没有，对响应的两个方面都有贡献。从循环到肺部的募集方面，中性粒细胞依赖于Mac-1和alpha（4）beta（1），而T细胞完全依赖于alpha（4）beta（1）。第二，免疫组织化学结果表明粘附在感染的肺组织本身中也起作用。 ICAM-1在肺组织中广泛表达。使用ICAM-1（-/-）小鼠显示，嗜中性粒细胞利用这种Mac-1配体，不是用于肺部进入或在肺组织内迁移，而是用于抵抗肺炎球菌感染。与ICAM-1相比，细支气管上的alpha（4）beta（1）配体VCAM-1受限制且组成性表达，从而允许白细胞通过这种整合素直接进入气道。肺炎球菌感染。因此，整合素Mac-1和alpha（4）beta（1）在调节疾病中性粒细胞和T细胞向受感染肺部的募集以及影响其在肺组织内部的行为时，在预防疾病期间的肺炎球菌生长方面具有举足轻重的作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号