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首页> 外文期刊>The Journal of Immunology: Official Journal of the American Association of Immunologists >The Latent Reservoir for HIV-1: How Immunologic Memory and Clonal Expansion Contribute to HIV-1 Persistence
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The Latent Reservoir for HIV-1: How Immunologic Memory and Clonal Expansion Contribute to HIV-1 Persistence

机译：HIV-1的潜在存储库：免疫记忆和克隆扩展如何促进HIV-1持久性

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摘要

Combination antiretroviral therapy (ART) for HIV-1 infection reduces plasma virus levels to below the limit of detection of clinical assays. However, even with prolonged suppression of viral replication with ART, viremia rebounds rapidly after treatment interruption. Thus, ART is not curative. The principal barrier to cure is a remarkably stable reservoir of latent HIV-1 in resting memory CD4(+) T cells. In this review, we consider explanations for the remarkable stability of the latent reservoir. Stability does not appear to reflect replenishment from new infection events but rather normal physiologic processes that provide for immunologic memory. Of particular importance are proliferative processes that drive clonal expansion of infected cells. Recent evidence suggests that in some infected cells, proliferation is a consequence of proviral integration into host genes associated with cell growth. Efforts to cure HIV-1 infection by targeting the latent reservoir may need to consider the potential of latently infected cells to proliferate.
机译：针对HIV-1感染的联合抗逆转录病毒疗法（ART）可将血浆病毒水平降至临床检测限度以下。但是，即使用ART长期抑制病毒复制，治疗后病毒血症也会迅速反弹。因此，ART不能治愈。治愈的主要障碍是静息记忆CD4（+）T细胞中潜在HIV-1的显着稳定储库。在这篇综述中，我们考虑了潜在储层非凡稳定性的解释。稳定性似乎并未反映出新感染事件的补充，而是反映了提供免疫记忆的正常生理过程。特别重要的是驱动感染细胞克隆扩增的增殖过程。最近的证据表明，在某些感染的细胞中，增殖是原病毒整合到与细胞生长相关的宿主基因中的结果。通过靶向潜伏库来治疗HIV-1感染的工作可能需要考虑潜伏感染的细胞增殖的潜力。

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