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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Convergent motor patterns from divergent circuits.
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Convergent motor patterns from divergent circuits.

机译：来自发散电路的收敛电动机模式。

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Neuromodulation changes the cellular and synaptic properties of neurons, thereby enabling individual neuronal circuits to generate multiple activity patterns. However, distinct modulatory inputs could conceivably also cona different motor circuits to generate similar activity patterns. Using the isolated stomatogastric ganglion (STG) of the crab Cancer borealis, we showed previously that pyrokinin (PK) peptides activate the gastric mill (chewing) rhythm without the participation of the projection neuron modulatory commissural neuron 1 (MCN1). MCN1, which does not contain the PK peptide, also activates the gastric mill rhythm and, at these times, is a gastric mill central pattern generator (CPG) neuron. Here, we show that the gastric mill rhythms elicited by PK superfusion and MCN1 stimulation in the isolated STG are comparable, in contrast to the distinct gastric mill rhythms elicited by other input pathways. We also identified several cellular and synaptic mechanisms underlying the PK- and MCN1-elicited gastric mill rhythms that are distinct, including additional differences in their core CPG neurons. For example, the presence of the inhibitory synapse from the pyloric pacemaker neuron anterior burster onto the gastric mill CPG was necessary only for generation of the PK-elicited gastric mill rhythm. Similarly, the dorsal gastric motor neuron regulated only the PK rhythm, apparently because of PK-mediated enhancement of its synaptic actions. Thus, we demonstrate that different modulatory inputs can elicit comparable, as well as distinct activity patterns from the same neuronal ensemble. Moreover, these comparable rhythms can result from distinct CPGs using overlapping, but distinct sets of cellular and synaptic mechanisms.
机译：神经调节改变神经元的细胞和突触特性，从而使单个神经元回路产生多种活动模式。但是，可以想象，不同的调制输入也可以使不同的电动机电路产生相似的活动模式。使用孤立的蟹癌的胃气管神经节（STG），我们以前表明，在不涉及投射神经元调节性连合神经元1（MCN1）参与的情况下，焦激酶（PK）肽可激活胃磨（咀嚼）节律。不包含PK肽的MCN1也可激活胃磨的节律，在这些时候，它是胃磨的中央模式发生器（CPG）神经元。在这里，我们显示，与其他输入途径引起的截然不同的胃碾声节律相反，在孤立的STG中由PK灌注和MCN1刺激引起的胃碾声节律是可比的。我们还确定了几种不同的细胞和突触机制，这些机制是由PK和MCN1引起的胃磨节律所不同的，包括其核心CPG神经元的其他差异。例如，从幽门起搏器神经元前突到胃磨CPG的抑制性突触的存在仅对于产生PK引起的胃磨节律是必要的。同样，胃背面运动神经元仅调节PK节律，这显然是因为PK介导的突触功能增强。因此，我们证明了不同的调节输入可以引起相同神经元集合的可比以及不同的活动模式。而且，这些可比的节律可以由使用重叠但不同组的细胞和突触机制的不同CPG产生。

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