• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Firing-pattern-dependent specificity of cortical excitatory feed-forward subnetworks.
【24h】

Firing-pattern-dependent specificity of cortical excitatory feed-forward subnetworks.

机译：皮质兴奋性前馈子网络的射击模式依赖性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The cortical circuit includes networks of highly interconnected pyramidal neurons. Here, we investigated whether pyramidal cells form subnetworks depending on pyramidal subtypes. We classified layer V (L5) pyramidal cells in rat frontal cortex into three physiological subtypes based on the presence (SA-d type) or absence (SA type) of an initial burst in neurons displaying slowly adapting spike trains, or fast spike frequency adaptation (FA type) against current pulse injections. Pyramidal cells projecting to the particular subcortical areas were correlated with the physiological subtypes. Focal glutamate stimulation of a L2/3 pyramidal cell induced EPSCs in SA and SA-d cells more frequently than in FA cells. FA cells in upper L5 received more inputs from the upper L2/3, and those in lower L5 received inputs from cells in lower L2/3, suggesting topographic interlaminar projections to FA cells. Dual recordings from L5 pyramidal cells revealed that common input probability that two L5 cells share inputs from a L2/3 cell was high in cell pairs of the same subtypes, compared with those in different subtype pairs. Furthermore, the common input probability was highly selective when cell pairs of the same subtypes, but not different subtypes, had connections between them. Our results suggest that L2/3 pyramidal cells selectively innervate L5 cells, depending on their firing subtypes.
机译：皮层回路包括高度互连的锥体神经元网络。在这里，我们研究了锥体细胞是否根据锥体亚型形成子网络。我们根据显示缓慢适应峰值序列或快速适应峰值频率的神经元中初始爆发的存在（SA-d类型）或不存在（SA类型），将大鼠额叶皮质中的V层（L5）锥体细胞分为三种生理亚型。 （FA型）防止电流脉冲注入。投射到特定皮层下区域的锥体细胞与生理亚型相关。局部谷氨酸刺激L2 / 3锥体细胞诱导的SASC和SA-d细胞中的EPSC的频率高于FA细胞。上层L5中的FA单元从上层L2 / 3接收更多的输入，而下层L5的FA单元从下层L2 / 3的单元接收输入，这表明对FA单元的层间地形投影。 L5锥体细胞的双重记录显示，与相同亚型的细胞对相比，两个L5细胞共享来自L2 / 3细胞的输入的共同输入概率较高。此外，当相同亚型而不是不同亚型的细胞对之间具有联系时，公共输入概率具有很高的选择性。我们的结果表明，L2 / 3锥体细胞选择性地支配L5细胞，具体取决于它们的放电亚型。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号