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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Pallidal neuron activity increases during sensory relay through thalamus in a songbird circuit essential for learning.
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Pallidal neuron activity increases during sensory relay through thalamus in a songbird circuit essential for learning.

机译：在对学习至关重要的鸣禽电路中，通过丘脑的感觉传递过程中，苍白神经元活动增加。

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Disinhibition of the thalamus remains the primary model of information transfer between the basal ganglia and the cortex. Yet in apparent conflict with this model, the globus pallidus, a GABAergic basal ganglia output structure, often exhibits marked increases in firing rate during movement. To investigate the translation of pallidal activity and its relay through the thalamus, we explored a basal ganglia-thalamic pathway essential for song learning in songbirds. We found that single units in the thalamic nucleus DLM of urethane-anesthetized adult male zebra finches responded selectively to playback of the bird's own song, like neurons in its upstream and downstream nuclei. Because the pallidal input to these neurons forms giant calyx-like synapses, we were able to record extracellular signals from these presynaptic terminals as well. Pallidal units were distinctly excited by song playback, suggesting an increase in GABAergic transmission in the thalamus during sensory processing. However, this overallincreased firing rate was phasic, punctuated by rapid decelerations in firing rate. In several cases, we were able to record presynaptic and postsynaptic units simultaneously. Correlating the presynaptic and postsynaptic activity, we found that disinhibition of thalamus may entail pallidal firing rate decelerations rather than simple long pauses in spontaneous activity, as has long been assumed.
机译：丘脑的抑制仍然是基底神经节和皮质之间信息传递的主要模型。然而，与该模型明显矛盾的是，苍白球（一种GABA能的基底神经节输出结构）在运动过程中经常表现出明显的射速增加。为了研究苍白球活动及其在丘脑中的传递的翻译，我们探索了一种基础神经节-丘脑通路，对于鸣禽的歌曲学习至关重要。我们发现，氨基甲酸酯麻醉的成年雄性斑马雀的丘脑核DLM中的单个单元选择性地响应鸟的自身歌曲的回放，就像其上游和下游核中的神经元一样。因为这些神经元的苍白细胞输入形成了巨大的萼状突触，所以我们也能够记录这些突触前末端的细胞外信号。歌曲播放使苍白的单位明显兴奋，表明感觉过程中丘脑中GABA能传递增加。但是，总体而言，这种增加的点火速率是阶段性的，被点火速率的快速减速所打断。在某些情况下，我们能够同时记录突触前和突触后单位。与突触前和突触后的活动相关，我们发现丘脑的抑制作用可能导致苍白球的放电速度减慢，而不是长期以来就假定的自然活动的简单长时间停顿。

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