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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >GABA transporter-1 activity modulates hippocampal theta oscillation and theta burst stimulation-induced long-term potentiation
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GABA transporter-1 activity modulates hippocampal theta oscillation and theta burst stimulation-induced long-term potentiation

机译：GABA转运蛋白1活性调节海马theta振荡和theta爆发刺激引起的长期增强

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摘要

The network oscillation and synaptic plasticity are known to be regulated by GABAergic inhibition, but how they are affected by changes in the GABA transporter activity remains unclear. Here we show that in the CA1 region of mouse hippocampus, pharmacological blockade or genetic deletion of GABA transporter-1 (GAT1) specifically impaired long-term potentiation (LTP) induced by theta burst stimulation, but had no effect on LTP induced by high-frequency stimulation or long-term depression induced by low-frequency stimulation. The extent of LTP impairment depended on the precise burst frequency, with significant impairment at 3-7 Hz that correlated with the time course of elevated GABAergic inhibition caused by GAT1 disruption. Furthermore, in vivo electrophysiological recordings showed that GAT1 gene deletion reduced the frequency of hippocampal theta oscillation. Moreover, behavioral studies showed that GAT1 knock-out mice also exhibited impaired hippocampus-dependent learning and memory. Together, these results have highlighted the important link between GABAergic inhibition and hippocampal theta oscillation, both of which are critical for synaptic plasticity and learning behaviors.
机译：已知网络振荡和突触可塑性受GABA能抑制的调节，但如何受GABA转运蛋白活性变化的影响尚不清楚。在这里，我们显示，在小鼠海马CA1区中，药理学封锁或GABA转运蛋白1（GAT1）的基因缺失特别损害了theta爆发刺激诱导的长期增强（LTP），但对高剂量诱导的LTP没有影响频率刺激或低频刺激引起的长期抑郁。 LTP损伤的程度取决于精确的猝发频率，在3-7 Hz处有明显的损伤，这与由GAT1破坏引起的升高的GABA能抑制的时间过程有关。此外，体内电生理学记录显示，GAT1基因缺失降低了海马theta振荡的频率。此外，行为研究表明，GAT1基因敲除小鼠还表现出海马依赖性学习和记忆受损。总之，这些结果突出了GABA能抑制与海马theta振荡之间的重要联系，这两者对于突触可塑性和学习行为至关重要。

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