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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Motoneurons dedicated to either forward or backward locomotion in the nematode Caenorhabditis elegans.
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Motoneurons dedicated to either forward or backward locomotion in the nematode Caenorhabditis elegans.

机译：致力于线虫秀丽隐杆线虫的向前或向后运动的动子。

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摘要

Multifunctional motoneurons and muscles, which are active during forward and backward locomotion are ubiquitous in animal models. However, studies in the nematode Caenorhabditis elegans suggest that some locomotor motoneurons are necessary only for forward locomotion (dorsal B-motoneurons, DB), while others (dorsal A-motoneurons, DA) are necessary only for backward locomotion. We tested this hypothesis directly by recording the activity of these motoneurons during semirestrained locomotion. For this purpose, we used epifluorescence imaging of the genetically encoded calcium sensor cameleon, expressed in specific motoneurons, while monitoring locomotor behavior through the microscope condenser using a second camera. We found that ventral and dorsal B-motoneurons (DB and VB) were coactive during forward locomotion while ventral A-motoneurons (VA) were only active during backward locomotion. The signals we recorded correlated with the direction of locomotion but not with the faster undulatory cycles. To our knowledge, these are the first recordings of motoneuron activity in C. elegans and the only direction-dedicated motoneurons described to date.
机译：在向前和向后运动期间活跃的多功能运动神经元和肌肉在动物模型中无处不在。但是，对线虫秀丽隐杆线虫的研究表明，某些运动型运动神经元仅对于向前运动是必需的（背侧B型运动神经元，DB），而其他运动型（背侧A型运动神经元，DA）仅对后向运动是必需的。我们通过记录这些运动神经元在半约束运动过程中的活动直接检验了这一假设。为此，我们使用了遗传编码的钙传感器喀麦隆的落射荧光成像（在特定的运动神经元中表达），同时使用第二台摄像机通过显微镜聚光镜监测了运动行为。我们发现，腹侧和背侧B运动神经元（DB和VB）在正向运动过程中共同起作用，而腹侧A运动神经元（VA）仅在向后运动过程中活跃。我们记录的信号与运动方向相关，但与更快的波动周期无关。据我们所知，这些是秀丽隐杆线虫中运动神经元活性的第一个记录，也是迄今为止描述的唯一的方向专用运动神经元。

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