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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Postnatal switch from synaptic to extrasynaptic transmission between interneurons and NG2 cells.
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Postnatal switch from synaptic to extrasynaptic transmission between interneurons and NG2 cells.

机译：产后从interneurons和NG2细胞之间的突触传递到突触外传递。

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摘要

NG2 cells, oligodendrocyte precursors, play a critical role in myelination during postnatal brain maturation, but a pool of these precursors is maintained in the adult and recruited to lesions in demyelinating diseases. NG2 cells in immature animals have recently been shown to receive synaptic inputs from neurons, and these have been assumed to persist in the adult. Here, we investigated the GABAergic synaptic activity of NG2 cells in acute slices of the barrel cortex of NG2-DsRed transgenic mice during the first postnatal month, which corresponds to the period of active myelination in the neocortex. Our data demonstrated that the frequency of spontaneous and miniature GABAergic synaptic activity of cortical NG2 cells dramatically decreases after the second postnatal week, indicating a decrease in the number of synaptic inputs onto NG2 cells during development. However, NG2 cells still receive GABAergic inputs from interneurons in the adult cortex. These inputs do not rely on the presence of functional synapses but involve a form of GABA spillover. This GABA volume transmission allows interneurons to induce phasic responses in target NG2 cells through the activation of extrasynaptic GABA(A) receptors. Hence, after development is complete, volume transmission allows NG2 cells to integrate neuronal activity patterns at frequencies occurring during in vivo sensory stimulation.
机译：NG2细胞（少突胶质细胞前体）在出生后大脑成熟过程中的髓鞘形成中起着关键作用，但是这些前体的集合在成年人中得以维持，并被招募至脱髓鞘疾病的病变中。最近显示，未成熟动物中的NG2细胞会接受神经元的突触输入，并且假定它们会持续存在于成年动物中。在这里，我们研究了出生后第一个月的NG2-DsRed转基因小鼠桶状皮质的急性切片中NG2细胞的GABA能突触活性，这对应于新皮层的活跃髓鞘形成时期。我们的数据表明，皮层NG2细胞自发和微型GABA能突触活性的频率在产后第二周后急剧下降，这表明发育过程中向NG2细胞的突触输入数量减少。但是，NG2细胞仍然从成年皮层中神经元接收GABA能输入。这些输入不依赖功能性突触的存在，而是涉及GABA溢出的一种形式。这种GABA的体积传递使中间神经元能够通过突触外GABA（A）受体的激活在目标NG2细胞中诱导阶段性反应。因此，在发育完成后，体积传递使NG2细胞以体内感觉刺激期间发生的频率整合神经元活动模式。

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