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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Action potentials initiate in the axon initial segment and propagate through axon collaterals reliably in cerebellar Purkinje neurons.
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Action potentials initiate in the axon initial segment and propagate through axon collaterals reliably in cerebellar Purkinje neurons.

机译：动作电位起始于轴突初始节段，并在小脑浦肯野神经元中可靠地通过轴突侧支传播。

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摘要

Purkinje neurons are the output cells of the cerebellar cortex and generate spikes in two distinct modes, known as simple and complex spikes. Revealing the point of origin of these action potentials, and how they conduct into local axon collaterals, is important for understanding local and distal neuronal processing and communication. By using a recent improvement in voltage-sensitive dye imaging technique that provided exceptional spatial and temporal resolution, we were able to resolve the region of spike initiation as well as follow spike propagation into axon collaterals for each action potential initiated on single trials. All fast action potentials, for both simple and complex spikes, whether occurring spontaneously or in response to a somatic current pulse or synaptic input, initiated in the axon initial segment. At discharge frequencies of less than approximately 250 Hz, spikes propagated faithfully through the axon and axon collaterals, in a saltatory manner. Propagation failures were only observed for very high frequencies or for the spikelets associated with complex spikes. These results demonstrate that the axon initial segment is a critical decision point in Purkinje cell processing and that the properties of axon branch points are adjusted to maintain faithful transmission.
机译：浦肯野神经元是小脑皮层的输出细胞，并以两种不同的模式产生尖峰，称为简单尖峰和复杂尖峰。揭示这些动作电位的起源，以及它们如何作用于局部轴突侧支，对于理解局部和远端神经元的加工和交流非常重要。通过使用电压敏感型染料成像技术的最新改进，该技术可提供出色的空间和时间分辨率，我们能够解决尖峰引发的区域，并跟踪针对单个试验中引发的每个动作电位的尖峰传播到轴突侧支中。在轴突初始部分中，所有的快速动作电位，无论是自然发生的还是响应体细胞电流脉冲或突触输入的，无论是简单的还是复杂的尖峰。在放电频率小于约250 Hz时，尖峰以咸化方式忠实地传播通过轴突和轴突侧支。仅在非常高的频率或与复杂尖峰相关的小尖峰中观察到传播失败。这些结果表明，轴突起始节段是浦肯野细胞加工中的关键决策点，并且调整了轴突分支点的属性以保持忠实的传输。

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