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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Direction-selective ganglion cells show symmetric participation in retinal waves during development.
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Direction-selective ganglion cells show symmetric participation in retinal waves during development.

机译：方向选择性神经节细胞在发育过程中显示对称参与视网膜波。

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摘要

Direction-selective ganglion cells (DSGCs) fire robustly for stimuli moving along one direction of motion and are strongly inhibited by stimuli moving in the opposite, or null, direction. In contrast to direction-selective neurons in primary visual cortex, a role for neural activity in the development of direction-selective retinal circuits has not been established. Direction-selective responses are detected at eye opening, before which spontaneous correlated activity known as retinal waves provide directional input to ganglion cells. Indeed, we observed a significant bias in wave propagation along the nasal over temporal direction. Using simultaneous calcium imaging and cell-attached recordings from three genetically labeled DSGC types in mice, we observed that all three DSGC types fire action potentials during retinal waves. However, we found that the direction of wave propagation did not influence DSGC spiking. These results indicate that the mechanisms guiding the formation of the asymmetric inhibition underlying direction selectivity in the retina are not dependent upon the directional properties of retinal waves.
机译：方向选择神经节细胞（DSGC）对于沿一个运动方向运动的刺激物具有较强的发射能力，并受到沿相反方向或无效方向运动的刺激物的强烈抑制。与初级视皮层中的方向选择神经元相反，尚未确定神经活动在方向选择性视网膜回路发育中的作用。在睁眼之前检测到方向选择性响应，然后称为视网膜波的自发相关活动向神经节细胞提供方向性输入。确实，我们观察到在沿时间方向沿鼻的波传播中存在明显的偏差。使用同时进行的钙成像和来自小鼠中三种经过基因标记的DSGC类型的细胞附着记录，我们观察到所有三种DSGC类型在视网膜波中都具有动作电位。但是，我们发现波的传播方向不影响DSGC峰值。这些结果表明，指导视网膜中方向选择性的不对称抑制作用形成的机制并不取决于视网膜波的方向特性。

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