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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Spectral integration in primary auditory cortex attributable to temporally precise convergence of thalamocortical and intracortical input.
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Spectral integration in primary auditory cortex attributable to temporally precise convergence of thalamocortical and intracortical input.

机译：初级听觉皮层的光谱积分归因于丘脑皮层和皮层内输入的时间精确收敛。

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摘要

Primary sensory cortex integrates sensory information from afferent feedforward thalamocortical projection systems and convergent intracortical microcircuits. Both input systems have been demonstrated to provide different aspects of sensory information. Here we have used high-density recordings of laminar current source density (CSD) distributions in primary auditory cortex of Mongolian gerbils in combination with pharmacological silencing of cortical activity and analysis of the residual CSD, to dissociate the feedforward thalamocortical contribution and the intracortical contribution to spectral integration. We found a temporally highly precise integration of both types of inputs when the stimulation frequency was in close spectral neighborhood of the best frequency of the measurement site, in which the overlap between both inputs is maximal. Local intracortical connections provide both directly feedforward excitatory and modulatory input from adjacent cortical sites, which determine how concurrent afferent inputs are integrated. Through separate excitatory horizontal projections, terminating in cortical layers II/III, information about stimulus energy in greater spectral distance is provided even over long cortical distances. These projections effectively broaden spectral tuning width. Based on these data, we suggest a mechanism of spectral integration in primary auditory cortex that is based on temporally precise interactions of afferent thalamocortical inputs and different short- and long-range intracortical networks. The proposed conceptual framework allows integration of different and partly controversial anatomical and physiological models of spectral integration in the literature.
机译：初级感觉皮层整合来自传入前馈丘脑皮层投影系统和会聚皮质内微电路的感觉信息。两个输入系统已被证明可以提供不同方面的感官信息。在这里，我们结合蒙古沙鼠的初级听觉皮层中层流电流源密度（CSD）分布的高密度记录，结合皮质活性的药理学沉默和残余CSD的分析，以分离前馈的丘脑皮层贡献和皮质内层对光谱积分。我们发现，当刺激频率处于测量位置最佳频率的紧密频谱邻域中时，两种输入的时间高度精确的积分，其中两个输入之间的重叠最大。局部皮质内连接提供来自相邻皮质位点的直接前馈兴奋性和调节性输入，这决定了如何同时合并传入的输入。通过终止于皮质层II / III的单独的兴奋性水平投影，即使在较长的皮质距离上，也可以提供更大光谱距离内的刺激能量信息。这些投影有效地加宽了光谱调谐宽度。基于这些数据，我们提出了一种主要听觉皮层的频谱整合机制，该机制基于传入的丘脑皮质输入与不同的短程和远程皮质内网络在时间上的精确相互作用。所提出的概念框架允许在文献中整合光谱整合的不同且部分有争议的解剖和生理模型。

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