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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Morphologically distinct classes of relay cells exhibit regional preferences in the dorsal lateral geniculate nucleus of the mouse.
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Morphologically distinct classes of relay cells exhibit regional preferences in the dorsal lateral geniculate nucleus of the mouse.

机译：形态不同的中继细胞在小鼠背外侧膝状核中表现出区域偏好。

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摘要

A fundamental feature of the mammalian visual system is the presence of separate channels that work in parallel to efficiently extract and analyze specific elements of a visual scene. Despite the extensive use of the mouse as a model system, it is not clear whether such parallel organization extends beyond the retina to subcortical structures, such as the dorsal lateral geniculate (dLGN) of thalamus. To begin to address this, we examined the morphology of biocytin-filled relay cells recorded in dLGN of mice. Based on a quantitative assessment of their dendritic architecture, we found that even at early postnatal ages relay cells could be readily classified as X-like (biconical), Y-like (symmetrical), or W-like (hemispheric) and that each cell type was regionally specified in dLGN. X-like cells were confined primarily to the monocular ventral region of dLGN. Y-like cells occupied a central core that also contained ipsilateral eye projections, whereas W-like cells were found along the perimeter of dLGN. Similar to cat, Y-like cells were more prevalent than X- and W-like cells, and X-like cells tended to be smaller than other cell types. However, the dendritic fields of X- and W-like cells did not exhibit an orientation bias with respect to optic tract or boundaries of dLGN. Although we found clear morphological differences among relay cells, an analysis of their electrophysiological properties did not reveal any additional distinguishing characteristics. Overall, these data coupled with recent observations in the retina suggest that the mouse has many of the hallmark features of a system-wide parallel organization.
机译：哺乳动物视觉系统的基本特征是存在单独的通道，这些通道并行工作以有效地提取和分析视觉场景的特定元素。尽管将鼠标广泛用作模型系统，但尚不清楚这种平行组织是否延伸到视网膜以外的皮质下结构，例如丘脑的背外侧膝状肌（dLGN）。为了解决这个问题，我们检查了小鼠dLGN中记录的充满生物素的中继细胞的形态。根据对树突状结构的定量评估，我们发现，即使在出生后早期，中继细胞也可以很容易地分类为X形（双圆锥形），Y形（对称）或W形（半球形），并且每个细胞类型是在dLGN中指定的。 X样细胞主要局限于dLGN的单眼腹侧区域。 Y样细胞占据了中央核，该中央核也包含同侧眼部突起，而W样细胞则沿dLGN的周边被发现。与猫类似，Y型细胞比X型和W型细胞更为普遍，而X型细胞往往比其他类型的细胞要小。但是，X和W样细胞的树突场相对于dLGN的视线或边界没有取向偏差。尽管我们发现中继细胞之间明显的形态学差异，但对其电生理特性的分析并未发现任何其他区别特征。总的来说，这些数据加上最近在视网膜中的观察结果表明，鼠标具有系统范围内并行组织的许多标志性特征。

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