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Implementation of Neural Networks for the Identification of Single Molecules

机译:神经网络用于单分子鉴定的实现

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The effectiveness of neural networks and the optimization of parameters for implementing neural networks were evaluated for use in the identification of single molecules according to their fluorescence lifetime. The best network architecture and training parameters were determined for both ideal and nonideal single-molecule fluorescence data. The effectiveness of the neural network is compared to that of the maximum likelihood estimator on the basis of its ability to correctly identify single molecules. For ideal single-molecule data, it was found that the neural networks and the maximum likelihood estimator perform approximately equally well. For nonideal single-molecule fluorescence data, neural networks were able to correctly identify a larger percentage of single-molecule events than the MLE method.
机译:评价了神经网络的有效性和用于实现神经网络的参数优化,以根据其荧光寿命来鉴定单分子。确定了理想和非理想单分子荧光数据的最佳网络架构和训练参数。根据神经网络正确识别单个分子的能力,将其与最大似然估计器的有效性进行比较。对于理想的单分子数据,发现神经网络和最大似然估计器的性能大致相同。对于非理想的单分子荧光数据,与MLE方法相比,神经网络能够正确识别更大比例的单分子事件。

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