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首页> 外文期刊>The journal of physical chemistry, A. Molecules, spectroscopy, kinetics, environment, & general theory >Quantitative mass spectrometric identification of isomers applying coherent laser control
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Quantitative mass spectrometric identification of isomers applying coherent laser control

机译:相干激光控制对异构体的定量质谱鉴定

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Mass spectrometry (MS) is one of the oldest and most trusted analytical methods for chemical identification. Advances in biology, such as metabolic analysis and proteomics, have fueled a growing number of refinements in this method. Unfortunately, isomers, for example, o- and p-xylene, are seldom identifiable by MS because they produce identical spectra. Time-consuming and less sensitive multidimensional methods are subsequently required for structural determination. The sensitivity of MS coupled with shaped femtosecond laser pulses that control molecular fragmentation and ionization results in a new, fast, and reproducible method for molecular identification which is used here to distinguish positional and geometric isomer compounds and quantify their relative concentration in mixtures.
机译:质谱(MS)是用于化学鉴定的最古老,最受信任的分析方法之一。生物学的进展,例如代谢分析和蛋白质组学,推动了这种方法的不断完善。不幸的是,异构体(例如邻二甲苯和对二甲苯)很难通过质谱鉴定,因为它们会产生相同的光谱。随后需要耗时且灵敏度较低的多维方法进行结构确定。 MS的灵敏度与控制分子分裂和电离的成形飞秒激光脉冲相结合,导致了一种新的,快速且可重现的分子鉴定方法,该方法可用于区分位置异构体和几何异构体化合物并定量其混合物中的相对浓度。

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