On the dynamics of fragment isomerization in collision-induced dissociation of peptides

Polfer NC; Bohrer BC; Plasencia MD; Paizs B; Clemmer DE

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On the dynamics of fragment isomerization in collision-induced dissociation of peptides

机译：碰撞诱导的肽解离中的片段异构化动力学

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The structures of peptide collision-induced dissociation (CID) product ions are investigated using ion mobility/mass spectrometry techniques combined with theoretical methods. The cross-section results are consistent with a mixture of linear and cyclic structures for both b(4) and a(4) fragment ions. Direct evidence for cyclic structures is essential in rationalizing the appearance of fragments with scrambled (i.e., permutated) primary structures, as the cycle may not open up where it was initially formed. It is demonstrated here that cyclic and linear a(4) structures can interconvert freely as a result of collisional activation, implying that isomerization takes place prior to dissociation.

机译：使用离子迁移率/质谱技术结合理论方法研究了肽碰撞诱导解离（CID）产物离子的结构。横截面结果与b（4）和a（4）碎片离子的线性和环状结构的混合物一致。循环结构的直接证据对于合理化具有混乱（即排列的）一级结构的片段的外观至关重要，因为循环可能不会在最初形成的地方打开。在此证明，环状和线性a（4）结构可以由于碰撞活化而自由地相互转换，这意味着异构化发生在解离之前。

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《The journal of physical chemistry, A. Molecules, spectroscopy, kinetics, environment, & general theory》 |2008年第6期|共8页
作者
Polfer NC; Bohrer BC; Plasencia MD; Paizs B; Clemmer DE;
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正文语种 eng
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ION MOBILITY MEASUREMENTS; TANDEM MASS-SPECTROMETRY; PROTONATED PEPTIDES; PROTEIN DATABASE; IMS-IMS; SPECTRA; CONFORMATIONS; BIOMOLECULES; INFORMATION; ENKEPHALIN;

机译：离子迁移率测量;串联质谱;质子化肽;蛋白质数据库;IMS-IMS;光谱;构象;生物分子;信息;脑啡肽;

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1. On the dynamics of fragment isomerization in collision-induced dissociation of peptides [J] . Polfer NC, Bohrer BC, Plasencia MD, The journal of physical chemistry, A. Molecules, spectroscopy, kinetics, environment, & general theory . 2008,第6期

机译：碰撞诱导的肽解离中的片段异构化动力学
2. Proposal for a common nomenclature for peptide fragment ions generated following sequence scrambling during collision-induced dissociation [J] . Chawner R., Gaskell S.J., Eyers C.E. Rapid Communications in Mass Spectrometry: RCM . 2012,第2期

机译：关于碰撞诱导解离过程中序列加扰后产生的肽片段离子的通用命名建议
3. Effect of Peptide Fragment Size on the Propensity of Cyciization in Collision-Induced Dissociation: Oligoglycine b_2-b_8 [J] . Xian Chen, Long Yu, Jeffrey D. Steill, Journal of the American Chemical Society . 2009,第51期

机译：肽片段大小对碰撞诱导解离中寡糖化倾向的影响：寡甘氨酸b_2-b_8
4. Effect of Chain Length on "b" Fragment Structures in Collision-Induced Dissociation of Protonated Peptides [C] . Xian Chen, Long Yu, Jos Oomens, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：链长对质子化肽碰撞诱导解离的“B”片段结构的影响
5. Dependence of head-to-tail cyclization on primary structures of peptides in collision-induced dissociation [D] . Chen, Xian 2010

机译：从头到尾环化对碰撞诱导的解离中肽一级结构的依赖性
6. On the Dynamics of Fragment Isomerization in Collision-Induced Dissociation of Peptides [O] . Nick C. Polfer, Brian C. Bohrer, Manolo D. Plasencia, -1

机译：碰撞诱导肽解离中片段异构化的动力学
7. A Collision-Induced Dissociation Cleavable Isobaric Tag for Peptide Fragment Ion-Based Quantification in Proteomics [O] . Xiaobo Tian, Marcel P. de Vries, Hjalmar P. Permentier, 2020

机译：蛋白质组学中的肽片段离子定量的抗碰撞诱导的解离可切割的同位标签
8. Target Gas Effects on Collision-Induced Dissociation of Peptides in a Tandem Four-Sector Mass Spectrometer [R] . Wilson, W. D. 1991

机译：目标气体对串联四扇区质谱中碰撞诱导的肽解离的影响

On the dynamics of fragment isomerization in collision-induced dissociation of peptides

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