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首页> 外文期刊>The journal of physical chemistry, A. Molecules, spectroscopy, kinetics, environment, & general theory >Photoswitchable fluorescent dyads incorporating bodipy and [1,3]oxazine components
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Photoswitchable fluorescent dyads incorporating bodipy and [1,3]oxazine components

机译：结合了双联吡啶和[1,3]恶嗪成分的光开关荧光二元体

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摘要

We designed and synthesized three compounds incorporating a BODIPY fluorophore and an oxazine photochrome within the same molecular skeleton and differing in the nature of the linker bridging the two functional components. The [1,3]oxazine ring of the photochrome opens in less than 6 ns upon laser excitation in two of the three fluorophore-photochrome dyads. This process generates a 3H-indolium cation with a quantum yield of 0.02-0.05. The photogenerated isomer has a lifetime of 1-3 μs and reverts to the original species with first-order kinetics. Both photochromic systems tolerate hundreds of switching cycles with no sign of degradation. The visible excitation of the dyads is accompanied by the characteristic fluorescence of the BODIPY component. However, the cationic fragment of their photogenerated isomers can accept an electron or energy from the excited fluorophore. As a result, the photoinduced transformation of the photochromic component within each dyad results in the effective quenching of the BODIPY emission. Indeed, the fluorescence of these photoswitchable compounds can be modulated on a microsecond time scale with excellent fatigue resistance under optical control. Thus, our operating principles and choice of functional components can ultimately lead to the development of valuable photoswitchable fluorescent probes for the super-resolution imaging of biological samples.
机译：我们设计并合成了三种化合物，它们在同一分子骨架内结合了BODIPY荧光团和恶嗪光致变色剂，并且在连接两个功能组件的接头性质上有所不同。在三个荧光团-光敏染料二元组中的两个中，通过激光激发，光敏染料的[1,3]恶嗪环在不到6 ns的时间内打开。该过程产生具有0.02-0.05的量子产率的3H-吲哚阳离子。光生异构体的寿命为1-3μs，并恢复为具有一级动力学的原始物种。两种光致变色系统都可以承受数百个开关周期，而不会出现退化迹象。二元组的可见激发伴随着BODIPY组分的特征性荧光。然而，它们的光生异构体的阳离子片段可以接受来自激发的荧光团的电子或能量。结果，在每个二倍体中光致变色成分的光诱导转变导致BODIPY发射的有效猝灭。实际上，这些光可切换化合物的荧光可以在微秒级的时间范围内调制，并且在光学控制下具有出色的抗疲劳性。因此，我们的工作原理和功能组件的选择最终可以导致开发有价值的光开关荧光探针，用于生物样品的超分辨率成像。

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