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首页> 外文期刊>The journal of physical chemistry, A. Molecules, spectroscopy, kinetics, environment, & general theory >pH-Response Optimization of Amino-Substituted Tetraphenylporphyrin Derivatives as pH-Activatable Photosensitizers
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pH-Response Optimization of Amino-Substituted Tetraphenylporphyrin Derivatives as pH-Activatable Photosensitizers

机译：氨基取代的四苯基卟啉衍生物作为pH活化光敏剂的pH响应优化

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摘要

Amino-substituted tetraphenylporphyrin derivatives have been designed as pH-activatable photosensitizers for photodynamic cancer therapy. The photophysical processes of the monoamino-substituted derivative N1 and nonsubstituted derivative NO have been studied. The quantum yields of the fluorescence and photosensitization of singlet oxygen by N1 were very low in the neutral condition (OFF state), but these quantum yields were recovered by adding acid (ON state). These changes were not observed for NO; therefore, N1 is expected to be applicable as a pH-activatable photosensitizer. The ON/OFF switching mechanism of N1 has also been clarified. To optimize the pH response, tri- and tetraamino-substituted derivatives (N3 and N4) have also been explored. The pH response intensified as the number of amino groups increased. Furthermore, the ON/OFF switching ratio of N3 was 100, which is quite high.
机译：氨基取代的四苯基卟啉衍生物已被设计为可用于光动力癌症治疗的pH活化光敏剂。已经研究了单氨基取代的衍生物N1和非取代的衍生物NO的光物理过程。在中性条件下（OFF状态），N1对单线态氧的荧光和光敏化的量子产率非常低，但是通过添加酸（ON状态）可以回收这些量子产率。没有观察到这些变化。因此，预期N1可用作pH可活化的光敏剂。 N1的ON / OFF切换机制也已经阐明。为了优化pH响应，还研究了三氨基和四氨基取代的衍生物（N3和N4）。随着氨基数目的增加，pH反应增强。此外，N3的开/关切换比为100，这是相当高的。

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