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首页> 外文期刊>The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical >Highly Hydrophilic Fused Aggregates (Microsponges) from a C12 Spermine Bolaamphiphile
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Highly Hydrophilic Fused Aggregates (Microsponges) from a C12 Spermine Bolaamphiphile

机译：来自C12精胺Bolaamphiphile的高度亲水性熔融聚集体（微海绵）

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Bolaamphiphiles consist of two hydrophilic headgroups joined by a hydrophobic linker.They are known to self-assemble into yesicles,micelles,tubules and fibers.Here we report on the self-assembly of a 1,12-[N,N-bis(3-aminopropyl)-l,4-butane diamine] dodecane (12G1) in aqueous media into discrete nonbilayer nanoparticles and unusual fused highly hydrated sponge like structures.12G1,l,10-[ N,N-bis(3-aminopropyl)-1,4-butane diamine] decane (10G1),l,8-[N,N-bis(3-aminopropyl)-l,4-butane diamine] octane (8G1),and l-[N,N-bis(3-aminopropyl)-l,4-butane diamine] dodecane (12GO) were synthesized and their self-assembly studied.12GO was relatively insoluble in water and multilamellar vesicles were produced with this amphiphile and cholesterol.While no aggregation in aqueous media was recorded for either 10G1 or 8G1 up to a concentration of 20 mM,aggregation of 12G1 molecules was seen to take place at an aqueous concentration of 1.75 mM as determined using various fluorescent and colorimetric probes and surface tension measurements.Electron microscopy images revealed that 12G1 formed monolayer vesicles of 20 nm in size at a concentration of 2.6 mM and even larger fused aggregates when the concentration was increased to 35 mM.Fusion resulted from the bridging of vesicles by the bolaamphiphile molecules.12G1 aggregates encapsulated 23X more low molecular weight (4kD) FITC-dextran than high (250kD) molecular weight FITC-dextran,an indication of the limited volume of the hydrophilic domains.12G1 also encapsulated 137X more 4kD FITC-dextran than was encapsulated by conventional sorbitan monostearate vesicles.We conclude that highly hydrated aggregates consisting of fused monolayer vesicles with small discrete hydrophilic domains in a sponge like structure may be formed by the self-assembly of bolaamphiphiles.
机译：亲脂性双亲分子由两个亲水性头基组成，它们通过疏水性连接基连接。已知它们可以自组装成小叶，胶束，小管和纤维。在此我们报道1,12- [N，N-bis（3 -氨基丙基）-1,4-丁烷二胺]十二烷（12G1）在水性介质中形成离散的非双层纳米颗粒和异常融合的高度水合的海绵状结构。12G1,1,10-[N，N-双（3-氨基丙基）-1 ，4-丁烷二胺]癸烷（10G1），1,8- [N，N-双（3-氨基丙基）-1,4-丁烷二胺]辛烷（8G1）和1- [N，N-bis（3合成了（氨基丙基）-1,4-丁烷二胺]十二烷（12GO）并对其自组装进行了研究.12GO相对不溶于水，并由该两亲物和胆固醇生成多层囊泡，但在水性介质中未记录到聚集浓度高达20 mM的10G1或8G1，使用各种荧光和比色探针测定，在1.75 mM的水溶液浓度下会发生12G1分子的聚集电子显微镜图像显示12G1在2.6 mM的浓度下形成20 nm的单层囊泡，当浓度增加至35 mM时甚至形成更大的融合聚集体。融合是由于疏松两亲子分子桥接囊泡而引起的。 .12G1包封的低分子量（4kD）FITC-右旋糖酐比高（250kD）分子量的FITC-右旋糖酐多23倍，这表明亲水结构域的体积有限.12G1包封的4kD FITC-右旋糖酐也多137倍。我们得出的结论是，由博拉两亲物的自组装可形成高度水合的聚集体，其由海绵状结构中具有小的离散亲水域的稠合单层囊泡组成。

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