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首页> 外文期刊>The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical >Mixed Micelles Composed of Peptides and Gadolinium Complexes as Tumor-Specific Contrast Agents in MRI:A SANS Study
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Mixed Micelles Composed of Peptides and Gadolinium Complexes as Tumor-Specific Contrast Agents in MRI:A SANS Study

机译：由肽和Ga复合物组成的混合胶束，作为MRI中肿瘤特异性的对比剂：SANS研究

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A detailed structural investigation on mixed micelle aggregates as target-specific contrast agents for magnetic resonance imaging technique has been carried out by way of small angle neutron scattering measurements.These mixed micelles are formed by two new amphiphilic molecules formed by a bioactive peptide and a claw moiety.The first molecule,C_(18)H_(37)CONH(AdOO)_x-G-CCK_8 (C18L_xCCK8,x = 2,5),contains an 18-carbon-atom alky lie chain bound to the C-terminal of the cholecystokinin octapeptide amide (CCK 26-33 or CCK8) and is able to bind to the overexpressed CCK receptor of some tumor cells.The second molecule,C_(18)H_(37)CONHLys(DTPAGlu)CONH_2~(5~) (CISDTPAGlu) or its gadolinium complex [C_(18)H_(37)CONHLys(DTPAGlu)-CONF^Gd]~(2-),ClSDTPAGlu(Gd),contains the same 18-carbon-atom alkylic chain bound,through a lysine residue,to the DTPAGlu chelating agent.Small angle neutron scattering measurements have been performed on ternary systems at different total concentrations and at various ratios of the two molecules.The effect of the concentration on the aggregation number as well as on the shape of the micelle has been investigated.Furthermore in order to optimize the exposure of the peptide on the micelle surface,C_(18)L_xCCK8 having the spacer L of different length has been used.The pure binary systems of the synthesized molecules are also presented.
机译：通过小角度中子散射测量，对混合胶束聚集体作为目标特异性造影剂进行了磁共振成像技术的详细结构研究，这些混合胶束由生物活性肽和爪形成的两个新的两亲分子形成第一个分子C_（18）H_（37）CONH（AdOO）_x-G-CCK_8（C18L_xCCK8，x = 2,5）包含与C的C端结合的18个碳原子的烷基lie链。第二个分子C_（18）H_（37）CONHLys（DTPAGlu）CONH_2〜（5〜）（ CISDTPAGlu）或其g络合物[C_（18）H_（37）CONHLys（DTPAGlu）-CONF ^ Gd]〜（2-），ClSDTPAGlu（Gd）包含通过赖氨酸键合的相同的18个碳原子的烷基链在三元体系上以不同的总浓度和不同的浓度对小角中子散射进行了测量研究了浓度对聚集数和胶束形状的影响。此外，为了优化肽在胶束表面上的暴露，具有C_（18）L_xCCK8的使用了不同长度的间隔基L.还给出了合成分子的纯二元体系。

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