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Anomalous Diffusion of Fatty Acid Vesicles Driven by Adhesion Gradients

机译:粘附梯度驱动的脂肪酸囊泡的异常扩散

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摘要

The motion of fatty acid vesicles driven by adhesion gradients of a liquid substrate (Langmuir monolayer) has been investigated. Trajectories of the vesicle motion reveal not only heterogeneity among vesicles in different regions of the monolayer but also heterogeneity within single-vesicle trajectories. Trajectories often exhibit complex behaviors such as circular and oscillating ones. Some vesicles exhibit intermittent dynamics that results in jump diffusion trajectories. In many vesicles their mean square displacements and effective diffusion coefficients exhibit a wide range of behaviors: (i) simple Brownian, (ii) subdiffusive, (iii) superdiffusive, and (iv) their combined motions. Even in the resting regime that the vesicle does not move substantially it exhibits active fluctuations due to spatio-temporal variations of the adhesion gradients of the monolayer. The results are compared with those in motor protein-driven transport of micrometer-sized particles bound to the cytoskeletal network and polymerization motor transport in the cell previously reported.
机译:已经研究了由液体基质(Langmuir单层)的粘附梯度驱动的脂肪酸囊泡的运动。囊泡运动的轨迹不仅揭示了单层不同区域内囊泡之间的异质性,而且揭示了单囊泡轨迹内的异质性。轨迹通常表现出复杂的行为,例如圆形和振荡行为。一些囊泡表现出间歇性动力学,从而导致跳跃扩散轨迹。在许多囊泡中,它们的均方位移和有效扩散系数表现出广泛的行为:(i)简单的布朗函数,(ii)次扩散,(iii)超扩散和(iv)组合运动。即使在囊泡基本不运动的静止状态中,由于单层的粘附梯度的时空变化,它也表现出主动的波动。将该结果与先前报道的细胞中与细胞骨架网络结合的微米级颗粒的运动蛋白驱动的转运和聚合的电机转运的结果进行了比较。

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