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首页> 外文期刊>The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical >Two-dimensional miscibility studies of alamethicin and selected film-forming molecules
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Two-dimensional miscibility studies of alamethicin and selected film-forming molecules

机译：来回霉素和所选成膜分子的二维混溶性研究

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摘要

Alamethicin (ALM), a 20-amino acid antibiotic peptide (peptaibol) from fungal sources, was mixed in Langmuir monolayers with six different surfactants: semifluorinated (F6H18, F10H19, F8H10OH, F6H10SH) and hydrogenated (C18SH and DODAC), aimed at finding appropriate molecules for ALM incorporation for nanodevice construction. Alamethicin-containing mixed monolayers were investigated by means of surface manometry (pi-A isotherms) and Brewster angle microscopy (BAM). Our results show that only semifluorinated alkanes can serve as an appropriate material since they form miscible and homogeneous monolayers with ALM within the whole concentration range. All the remaining surfactants, possessing polar groups, were found to demix with ALM. This effect was explained as being due to the existence of strong polar interactions between vertically oriented surfactant molecules, which tend to separate from horizontally oriented a-helices of the peptide. On the contrary, semifluorinated alkanes, lacking any polar group in their structure and bearing a large dipole moment, interact with ALM, also possessing a huge cumulative dipole moment. These dipole-dipole interactions between ALM and SFAs are more attractive than those between SFA molecules in their pure monolayers, causing the large ALM molecule, situated parallel to the interface, to be surrounded by SFA molecules in perpendicular orientation, leading to the formation of a highly organized binary mixed monolayer. BAM images of the ALM monolayer indicate that this peptide collapses with the nucleation and growth mechanism, like the majority of surfactants, which contradicts the model of ALM collapse by desorption, previously published in the literature.
机译：Alamethicin（ALM），一种来自真菌的20个氨基酸的抗菌肽（peptaibol），在Langmuir单层中与六种不同的表面活性剂混合：半氟化（F6H18，F10H19，F8H10OH，F6H10SH）和氢化（C18SH和DODAC），目的是发现用于ALM掺入的合适分子用于纳米器件的构造。借助于表面测压法（pi-A等温线）和布鲁斯特角显微镜（BAM）研究了含丙甲霉素的混合单层。我们的结果表明，只有半氟化烷烃可以用作合适的材料，因为它们会在整个浓度范围内与ALM形成可混溶且均匀的单层。发现所有剩余的具有极性基团的表面活性剂都与ALM混合。解释该作用是由于垂直取向的表面活性剂分子之间存在强极性相互作用，该相互作用倾向于与肽的水平取向a螺旋分离。相反，结构中没有任何极性基团且带有大偶极矩的半氟化烷烃与ALM相互作用，也具有巨大的累积偶极矩。 ALM和SFA之间的这些偶极-偶极相互作用比纯分子单层中SFA分子之间的相互作用更具吸引力，导致平行于界面的大ALM分子在垂直方向上被SFA分子包围，导致形成高度组织化的二进制混合单层。 ALM单层的BAM图像表明，该肽具有成核和生长机理，就像大多数表面活性剂一样塌陷，这与文献中先前发表的与ALM通过解吸塌陷的模型相矛盾。

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