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首页> 外文期刊>The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical >Unusually High Efficiency of β-Cyclodextrin Clathrate Preparation by Water-Free Solid-Phase Guest Exchange
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Unusually High Efficiency of β-Cyclodextrin Clathrate Preparation by Water-Free Solid-Phase Guest Exchange

机译：无水固相客流交换制备β-环糊精包合物的效率异常高

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摘要

An effective preparation procedure is offered for β-cyclodextrin (bCD) clathrates with volatile guests of moderate hydrophilicity, which otherwise require a finely tuned optimization of the bCD/water/guest ratio. The proposed procedure includes guest exchange in a water-free bCD matrix. As a result, more stable clathrates with a higher inclusion capacity can be prepared than by direct saturation of dried or hydrated bCD. To find an optimal preparation method, the structure—property relationships were studied for four different ways of bCD clathrate formation with guests of varying molecular structure. The study was much simplified by used procedures excluding direct contact of guest and water liquids with bCD. Besides, in clathrate preparation experiments, the thermodynamic activities of water and guest were varied independently, which makes explicit the role of water in this process. Hydration of bCD reduces its inclusion threshold for hydrophobic guests by their activity (relative vapor pressure), giving favorable hydration effect for their inclusion. Besides, water competes with hydrophilic guests for binding sites in bCD at high water activities. Together with bCD dehydration by excess of hydrophilic guests, these observations give a complete thermodynamic picture, which may be fruitful for elaboration of guest encapsulation techniques by cyclodextrins.
机译：对于具有中等亲水性的挥发性客体的β-环糊精（bCD）包合物提供了有效的制备程序，否则将需要对bCD /水/客体比率进行微调优化。拟议的程序包括在无水bCD矩阵中进行来宾交换。结果，与通过干燥或水合的bCD的直接饱和相比，可以制备具有更高包容能力的更稳定的包合物。为了找到最佳的制备方法，研究了具有不同分子结构的来宾的四种不同bCD包合物形成方式的结构-性质关系。该研究通过使用程序大大简化，该程序排除了客体和水液体与bCD的直接接触。此外，在包合物制备实验中，水和客体的热力学活性是独立变化的，这清楚地表明了水在该过程中的作用。 bCD的水合通过其活性（相对蒸气压）降低了疏水性客体的包合阈值，从而为疏水性客体提供了良好的水合效果。此外，在高水分活动下，水与亲水性客体竞争bCD中的结合位点。这些观察结果与过量的亲水性客体引起的bCD脱水一起，提供了完整的热力学图景，这对于通过环糊精阐述客体包封技术可能是富有成果的。

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