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首页> 外文期刊>The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical >Thermoregulated Formation and Disintegration of Cationic Block Copolymer Vesicles: Fluorescence Resonance Energy Transfer Study
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Thermoregulated Formation and Disintegration of Cationic Block Copolymer Vesicles: Fluorescence Resonance Energy Transfer Study

机译：阳离子嵌段共聚物囊泡的温度调节形成和崩解：荧光共振能量转移研究

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摘要

Formation and disintegration of self-assembled nanostructures in response to external stimuli are important phenomena that have been widely explored for a variety of biomedical applications. In this contribution, we report the thermally triggered assembly of block copolymer molecules in aqueous solution to form vesicles (polymersomes) and their disassembly on reduction of temperature. A new thermores-ponsive diblock copolymer of poly(N-isopropylacrylamide) poly((3-methacrylamidopropyl)trimethylammonium chloride) (PNIPA-b-PMAPTAC) was synthesized by reversible addition—fragmentation chain transfer technique. The solution properties and self-assembling behavior of the block copolymer molecules were studied by turbidimetry, temperature-dependent proton nuclear magnetic resonance, fluorescence spectroscopy, dynamic light scattering, and transmission electron microscopy. Fluorescence resonance energy transfer studies between coumarin-153 (C-153, donor) and rhodamine 6G (R6G, acceptor) have been performed by steady-state and picosecond-resolved fluorescence spectroscopy to probe the structural and dynamic heterogeneity of the vesicles. The occurrence of efficient energy transfer was evident from the shortening of donor lifetime in the presence of the acceptor. The capability of the vesicles to encapsulate both hydrophobic and hydrophilic molecules and release them in response to decrease in temperature makes them potentially useful as drug delivery vehicles.
机译：响应外部刺激，自组装纳米结构的形成和分解是重要的现象，已广泛用于各种生物医学应用。在这一贡献中，我们报告了嵌段共聚物分子在水溶液中热触发组装以形成囊泡（聚合物小体）及其在降低温度时的分解。通过可逆加成-断裂链转移技术合成了一种新型的热敏性嵌段共聚物，该共聚物是聚（N-异丙基丙烯酰胺）聚（3-甲基丙烯酰胺基丙基）三甲基氯化铵（PNIPA-b-PMAPTAC）。通过比浊法，温度依赖性质子核磁共振，荧光光谱，动态光散射和透射电子显微镜研究了嵌段共聚物分子的溶液性质和自组装行为。香豆素153（C-153，供体）和若丹明6G（R6G，受体）之间的荧光共振能量转移研究已通过稳态和皮秒分辨荧光光谱进行，以探测囊泡的结构和动态异质性。有效的能量转移的发生从受体存在时供体寿命的缩短可以明显看出。囊泡包封疏水和亲水分子并响应于温度降低而释放它们的能力使得它们潜在地可用作药物递送载体。

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