Oxidation of Cholesterol Does Not Alter Significantly Its Uptake into High-Density Lipoprotein Particles

Karilainen Topi; Timr Stepan; Vattulainen Ilpo; Jungwirth Pavel

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Oxidation of Cholesterol Does Not Alter Significantly Its Uptake into High-Density Lipoprotein Particles

机译：胆固醇的氧化不会显着改变其对高密度脂蛋白颗粒的吸收

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Using replica exchange umbrella sampling we calculated free energy profiles for uptake of cholesterol and one of its oxysterols (7-ketocholesterol) from an aqueous solution into a high-density lipoprotein particle. These atomistic molecular dynamics simulations show that both sterols are readily taken up from the aqueous solution with comparable free energy minima at the surface of the particle of -17 kcal/mol for cholesterol and -14 kcal/mol for 7-ketocholesterol. Moreover, given its preferred position at the particle surface, 7-ketocholesterol is expected to be able to participate directly in biological signaling processes.

机译：使用仿制交换伞采样，我们计算了从水溶液到高密度脂蛋白颗粒中胆固醇及其一种氧固醇（7-酮胆固醇）摄取的自由能曲线。这些原子分子动力学模拟表明，两种固醇很容易从水溶液中吸收，胆固醇表面的自由能极小，胆固醇为-17 kcal / mol，7-酮胆固醇为-14 kcal / mol。而且，鉴于其在颗粒表面的优选位置，预期7-酮胆固醇能够直接参与生物信号传导过程。

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《The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical》 |2015年第13期|共7页
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Karilainen Topi; Timr Stepan; Vattulainen Ilpo; Jungwirth Pavel;
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1. Oxidation of Cholesterol Does Not Alter Significantly Its Uptake into High-Density Lipoprotein Particles [J] . Karilainen Topi, Timr Stepan, Vattulainen Ilpo, The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical . 2015,第13期

机译：胆固醇的氧化不会显着改变其对高密度脂蛋白颗粒的吸收
2. Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-associated cholesterol esters independent of its enzymic activity [J] . Strauss JG, Zimmermann R, Hrzenjak A, The Biochemical Journal . 2002,第0期

机译：内皮细胞衍生的脂肪酶介导高密度脂蛋白（HDL）颗粒的摄取和结合以及与HDL相关的胆固醇酯的选择性摄取，而与酶活性无关
3. Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-associated cholesterol esters independent of its enzymic activity. [J] . Strauss JG, Zimmermann R, Hrzenjak A, The Biochemical Journal . 2002,第Pta1期

机译：内皮细胞衍生的脂肪酶介导高密度脂蛋白（HDL）颗粒的摄取和结合以及与HDL相关的胆固醇酯的选择性摄取，而不受其酶促活性的影响。
4. The Postmenopausal Hormone Replacement Therapy Alters Lipoprotein Composition Leading to an Overestimation of its Low-Density Lipoprotein Cholesterol Lowering Effect [C] . J.L. Vicira, E.H. Moriguchi, M.E. Gomes, International Congress on Coronary Artery Disease . 2003

机译：绝经后激素替代疗法改变了脂蛋白组合物，导致其低密度脂蛋白胆固醇降低效果的高估
5. The effects of Bios Life and exercise on total cholesterol, serum low-density lipoprotein, and high-density lipoproteins [D] . Inderlied-Rucks, Lori Jan 2000

机译：Bios Life和运动对总胆固醇，血清低密度脂蛋白和高密度脂蛋白的影响
6. Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-associated cholesterol esters independent of its enzymic activity. [O] . Juliane G Strauss, Robert Zimmermann, Andelko Hrzenjak, 2002

机译：内皮细胞衍生的脂肪酶介导高密度脂蛋白（HDL）颗粒的摄取和结合以及与HDL相关的胆固醇酯的选择性摄取而不受其酶促活性的影响。
7. Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-associated cholesterol esters independent of its enzymic activity. [O] . Strauss, Juliane G, Zimmermann, Robert, Hrzenjak, Andelko, 2002

机译：内皮细胞衍生的脂肪酶介导高密度脂蛋白（HDL）颗粒的摄取和结合以及与HDL相关的胆固醇酯的选择性摄取，而不受其酶促活性的影响。

Oxidation of Cholesterol Does Not Alter Significantly Its Uptake into High-Density Lipoprotein Particles

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