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首页> 外文期刊>The journal of physical chemistry, C. Nanomaterials and interfaces >Logic-Based Dual-Functional DNA Tweezers with Protein and Small Molecule as Mechanical Activators
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Logic-Based Dual-Functional DNA Tweezers with Protein and Small Molecule as Mechanical Activators

机译：以蛋白质和小分子为机械激活剂的基于逻辑的双功能DNA镊子

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摘要

In the present work, dual-functional DNA tweezers were constructed for the multiplex detection of thrombin and adenosine triphosphate (ATP). The aptamers for thrombin and ATP were respectively immobilized on magnetic beads (MBs). Then they hybridized with complementary sequences at the ends of opening strands C_(in) and D_(in). In the presence of thrombin and ATP, C_(in) and D_(in) were released as the results of competition. The tweezers contained two symmetrical components, and six DNA strands were hybridized to form the closed state. When the opening strands were introduced, the tweezers were driven to the open state, releasing two inert double-stranded waste products.
机译：在本工作中，构建了双重功能的DNA镊子，用于凝血酶和三磷酸腺苷（ATP）的多重检测。凝血酶和ATP的适体分别固定在磁珠（MBs）上。然后，它们在开放链C_（in）和D_（in）的末端与互补序列杂交。在凝血酶和ATP的存在下，C_（in）和D_（in）作为竞争结果被释放。镊子包含两个对称成分，并且六个DNA链杂交形成闭合状态。当引入开口绞线时，镊子被驱动至打开状态，释放出两种惰性双链废料。

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