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首页> 外文期刊>Current computer-aided drug design >Cycloxygenase-2 (COX-2) - A Potential Target for Screening of Small Molecules as Radiation Countermeasure Agents: An In Silico Study
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Cycloxygenase-2 (COX-2) - A Potential Target for Screening of Small Molecules as Radiation Countermeasure Agents: An In Silico Study

机译：环氧合酶2（COX-2）-筛选小分子的潜在靶标作为放射对策：计算机模拟研究

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摘要

Over the past several decades a large number of natural and synthetic compounds were evaluated against radiation induced damage in a variety of living systems. However, because of adverse side effects and compromising efficacy, as of now there is no single druggable agent available for human application to protect against radiations injury [1]. Lack of clear profile about the pathways and targets perturbed by ionizing radiation is also an important hurdle in development of effective radiation countermeasure agents and there is a requirement for better predictive models along with the potential to screen a large number of chemical compounds quickly [2]. Indirect energy deposition and generation of reactive free radicals are responsible in a major way in induction of damage by low LET radiation [3]. At the molecular level, ionizing radiation cause damage to DNA, protein and lipids which can lead to downstream events like cell cycle arrest, apoptosis and a number of stress-related responses [4, 5]. It is also well established that local tissue damage triggers inflammatory response and the mediators such as histamine, kinins and prostaglandins are mainly generated by arachidonic acid cascade [6]. Two types of COX isoform (COX-1 and COX-2) have been reported to be responsible for the synthesis of prostaglandins
机译：在过去的几十年中，评估了许多天然和合成化合物在各种生物系统中抵抗辐射诱发的损害。然而，由于不良的副作用和损害的功效，到目前为止，尚无可用于人体应用的单一可药物化剂可防止辐射损伤[1]。对于电离辐射干扰的途径和目标缺乏清晰的认识也是开发有效的辐射对策剂的重要障碍，并且需要更好的预测模型以及快速筛选大量化合物的潜力[2] 。间接能量沉积和反应性自由基的产生主要是由于低LET辐射引起的损伤[3]。在分子水平上，电离辐射会破坏DNA，蛋白质和脂质，从而导致下游事件，例如细胞周期停滞，凋亡和许多与压力相关的反应[4，5]。众所周知，局部组织损伤会触发炎症反应，而组胺，激肽和前列腺素等介体主要是由花生四烯酸级联产生的[6]。据报道两种类型的COX同工型（COX-1和COX-2）负责前列腺素的合成

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