...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Urology >Cryptorchidism Concordance in Monozygotic and Dizygotic Twin Brothers, Full Brothers, and Half-Brothers
【24h】

Cryptorchidism Concordance in Monozygotic and Dizygotic Twin Brothers, Full Brothers, and Half-Brothers

机译：单卵和双卵双胞胎兄弟，全兄弟和同父异母兄弟中的隐睾症一致性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: To study concordance rates of cryptorchidism (undescended testis) in pairs of boys with varying family structure, to evaluate the risk contribution from the intrauterine environment and genetic factors. Design: Population based study of 1,024,500 Danish boys born from January 1, 1973 to December 31, 2004. Classic twin method and computerized square dance design. Setting: Hospitals and outpatient clinics. Patient(s): Six groups of boy pairs: boys with no relation, paternal half-brothers, maternal half-brothers, full brothers, dizygotic twin brothers, and monozygotic twin brothers. Intervention(s): Observational study. Main Outcome Measure(s): Status on each individual regarding cryptorchidism and orchiopexy from the Danish National Patient Register. Result(s): Concordance rates of cryptorchidism in the groups were as follows: boys with no relation 3.2% (95% confidence interval 2.7%-3.6%), paternal half-brothers 3.4% (2.3%-4.7%), maternal half-brothers 6.0% (4.5%-7.7%), full brothers 8.8% (8.3%-9.8%), dizygotic twin brothers 24.1% (16.0%-33.6%), and monozygotic twin brothers 27.3% (15.5%-41.2%). Conclusion(s): The concordance rate was higher in maternal than in paternal half-brothers, and much higher but of equal magnitude in both twin groups. The findings strongly support that the intrauterine environment and maternal inheritance are contributing to the occurrence of cryptorchidism.
机译：目的：研究不同家庭结构的成对男孩中隐睾症（睾丸未降序）的符合率，评估宫内环境和遗传因素对风险的贡献。设计：基于人口的研究，研究了1973年1月1日至2004年12月31日出生的1,024,500名丹麦男孩。经典的双胞胎方法和计算机化的广场舞设计。地点：医院和门诊诊所。患者：六对男孩对：没有亲戚的男孩，父亲的同父异母兄弟，母亲的同父异母兄弟，全兄弟，同卵双生兄弟和同卵双生兄弟。干预措施：观察性研究。主要观察指标：丹麦国家患者登记簿上每个患者隐睾症和睾丸异位症的状况。结果：各组隐睾症的符合率如下：无亲属的男孩3.2％（95％置信区间2.7％-3.6％），父亲的同父异母兄弟3.4％（2.3％-4.7％），母亲的一半-兄弟6.0％（4.5％-7.7％），全兄弟8.8％（8.3％-9.8％），同卵双生兄弟24.1％（16.0％-33.6％）和同卵双生兄弟27.3％（15.5％-41.2％） 。结论：孕产妇的一致率高于同父异母的兄弟，两个双胞胎组的一致性较高。这些发现强烈支持子宫内环境和母体遗传是隐睾症的发生原因。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号