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首页> 外文期刊>Current diabetes reports. >Newer agents for the treatment of painful diabetic peripheral neuropathy.
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Newer agents for the treatment of painful diabetic peripheral neuropathy.

机译：用于治疗糖尿病性周围神经病变的新型药物。

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摘要

Neuropathic pain is responsible for a significant amount of the morbidity associated with generalized and focal peripheral neuropathies in diabetes. It is a consequence of alterations in neuronal function, chemistry, and structure that occur secondary to nerve injury. A variety of agents from diverse pharmacologic classes, the so-called adjuvant analgesics, have been used to treat neuropathic pain. These include antidepressants, first- and second-generation anticonvulsants, antiarrhythmic agents, topical agents, N-methyl-d-aspartate receptor antagonists, and the opioid analgesics. The availability of several newer agents, used alone or in combination, has resulted in the successful alleviation of neuropathic pain in many patients. Recent advances in the understanding of pain mechanisms at multiple central nervous system levels should pave the way toward more effective treatment modalities with less prominent side effects.
机译：神经性疼痛是与糖尿病中广泛性和局灶性周围神经病相关的大量发病率的原因。这是神经损伤继发的神经元功能，化学和结构改变的结果。来自不同药理学类别的多种药物，即所谓的辅助镇痛药，已用于治疗神经性疼痛。这些药物包括抗抑郁药，第一代和第二代抗惊厥药，抗心律不齐药，局部用药，N-甲基-d-天冬氨酸受体拮抗剂和阿片类镇痛药。单独使用或组合使用的几种新型药物的使用，已成功缓解了许多患者的神经性疼痛。在多个中枢神经系统水平上对疼痛机制的理解方面的最新进展应为朝着更有效的治疗方式，副作用更少的方向铺平道路。

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