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Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease

机译:胰岛素抵抗,血脂异常和心脏代谢疾病中的异位脂肪

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摘要

Shulman (Sept. 18 issue) theorized that ectopic fat plays a major role in the development of insulin resistance. We speculate, however, that insulin resistance may be caused by another major pathway, in which glucose itself, at high levels, plays a critical role. Reasonable evidence has shown that when glucose levels are elevated, glucose molecules may randomly bind to proteins similar to the insulin receptor on the plasma membrane of the cell and in time become advanced glycation end products.
机译:Shulman(9月18日发行)推论说,异位脂肪在胰岛素抵抗的发生中起主要作用。但是,我们推测,胰岛素抵抗可能是由另一种主要途径引起的,其中高水平的葡萄糖本身起着至关重要的作用。合理的证据表明,当葡萄糖水平升高时,葡萄糖分子可能会随机结合至与细胞质膜上的胰岛素受体相似的蛋白质,并逐渐成为晚期糖基化终产物。

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