...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current Biology: CB >Role for the abi/wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling
【24h】

Role for the abi/wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling

机译：abi / wave蛋白复合体在T细胞受体介导的增殖和细胞骨架重塑中的作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: The molecular reorganization of signaling molecules after T cell receptor (TCR) activation is accompanied by polymerization of actin at the site of contact between a T cell and an antigen-presenting cell (APC), as well as extension of actin-rich lamellipodia around the APC. Actin polymerization is critical for the fidelity and efficiency of the T cell response to antigen. The ability of T cells to polymerize actin is critical for several steps in T cell activation including TCR clustering, mature immunological synapse formation, calcium flux, IL-2 production, and proliferation. Activation of the Rac GTPase has been linked to regulation of actin polymerization after TCR stimulation. However, the molecules required for TCR-mediated actin polymerization downstream of activated Rac have remained elusive. Here we identify a novel role for the Abi/Wave protein complex, which signals downstream of activated Rac, in the regulation of actin polymerization and T cell activation in response to TCR stimulation.
机译：背景：T细胞受体（TCR）激活后信号分子的分子重组伴随着肌动蛋白在T细胞与抗原呈递细胞（APC）接触部位的聚合，以及富含肌动蛋白的片状脂蛋白的延伸在APC周围。肌动蛋白聚合对于T细胞对抗原反应的保真度和效率至关重要。 T细胞聚合肌动蛋白的能力对于T细胞活化中的多个步骤至关重要，包括TCR聚类，成熟的免疫突触形成，钙通量，IL-2产生和增殖。 Rac GTPase的激活与TCR刺激后肌动蛋白聚合的调节有关。但是，TCR介导的活化Rac下游的肌动蛋白聚合所需的分子仍然难以捉摸。在这里，我们确定了Abi / Wave蛋白复合物的新作用，该复合物在激活的Rac下游发出信号，调节肌动蛋白聚合和响应TCR刺激的T细胞活化。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号