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Building Distinct Actin Filament Networks Review in a Common Cytoplasm

机译:在普通细胞质中建立不同的肌动蛋白丝网络评论

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摘要

Eukaryotic cells generate a diversity of actin filament networks in a common cytoplasm to optimally perform functions such as cell motility, cell adhesion, endocytosis and cytokinesis. Each of these networks maintains precise mechanical and dynamic properties by autonomously controlling the composition of its interacting proteins and spatial organization of its actin filaments. In this review, we discuss the chemical and physical mechanisms that target distinct sets of actin-binding proteins to distinct actin filament populations after nucleation, resulting in the assembly of actin filament networks that are optimized for specific functions.
机译:真核细胞在共同的细胞质中产生多种肌动蛋白丝网络,以最佳地执行诸如细胞运动,细胞粘附,内吞和胞质分裂的功能。这些网络中的每一个都通过自主控制其相互作用蛋白的组成和肌动蛋白丝的空间组织来维持精确的机械和动态特性。在这篇综述中,我们讨论了成核后将不同组的肌动蛋白结合蛋白靶向不同的肌动蛋白丝群体的化学和物理机制,从而导致针对特定功能进行优化的肌动蛋白丝网络的组装。

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