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Temporal variations and trends in loads of commonly used pharmaceuticals to large wastewater treatment plants in Sweden, a case study (Ryaverket)

机译:案例研究(Ryaverket)在瑞典大型废水处理厂中常用药品的时间变化和趋势

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摘要

Loads of individual commonly used analgesics (ibuprofen, diclofenac), antibiotics (sulfamethoxazole, trimethoprim), beta-blockers (atenolol, metoprolol, sotalol, propranolol) and neuroleptics (carbamazepine, citalopram) to a large-scale operating wastewater treatment plant (WWTP) in Sweden (Ryaverket) were studied by monitoring concentrations and flows during a 9-year period (2006-2015). Variations in loads due to sampling and possible errors in chemical analyses were estimated to be below 40%. The variations in loads were analyzed and discussed in terms of the design of collecting wastewater system as an integrated part of the water treatment at the WWTP as well as the prescription and use of individual pharmaceuticals. Trend analysis in daily loads of individual pharmaceuticals indicated an increase for diclofenac, no significant changes for ibuprofen and metoprolol and a decrease for the other pharmaceuticals. The latter was ascribed to a decrease in their prescription and use. The increase in loads of diclofenac was ascribed to its growing topical use not requiring prescription. In view of future regulations by the EU, growing loads of diclofenac to WWTPs and its low removal rates in WWTPs may require an upgrade of WWTPs to achieve quality standards for diclofenac in receiving waters.
机译:将大量常用的止痛药(布洛芬,双氯芬酸),抗生素(磺胺甲恶唑,甲氧苄氨嘧啶),β受体阻滞剂(阿替洛尔,美托洛尔,索他洛尔,普萘洛尔)和抗精神病药(卡马西平,西酞普兰)加到大规模的污水处理厂(WWTP)中在瑞典(Ryaverket)进行了为期9年(2006-2015年)的监测浓度和流量研究。由于采样和化学分析中可能存在的误差导致的负载变化估计低于40%。分析和讨论了负荷的变化,其中包括作为污水处理厂水处理的一个组成部分的收集废水系统的设计以及各个药品的处方和使用。个别药物日剂量的趋势分析表明双氯芬酸增加,布洛芬和美托洛尔无明显变化,其他药物减少。后者被归因于其处方和使用减少。双氯芬酸负荷的增加归因于其不断增长的局部使用而不需要处方。鉴于欧盟未来的法规,双氯芬酸在污水处理厂中的负荷不断增加,并且其在污水处理厂中的去除率较低,可能需要对污水处理厂进行升级,以达到接收水中双氯芬酸的质量标准。

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