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首页> 外文期刊>Vaccine >Passive immunization with Leptospira LPS-specific agglutinating but not non-agglutinating monoclonal antibodies protect guinea pigs from fatal pulmonary hemorrhages induced by serovar Copenhageni challenge
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Passive immunization with Leptospira LPS-specific agglutinating but not non-agglutinating monoclonal antibodies protect guinea pigs from fatal pulmonary hemorrhages induced by serovar Copenhageni challenge

机译：钩端螺旋体LPS特异性凝集而非非凝集单克隆抗体的被动免疫可保护豚鼠免受因血清型Copenhageni攻击引起的致命性肺出血

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摘要

Leptospira interrogans serovar Copenhageni causes pulmonary hemorrhages with respiratory failure, a major cause of death in leptospirosis patients. Protective immunity to Leptospira is known to correlate with the production of leptospiral lipopolysaccharide (L-LPS)-specific agglutinating antibodies. We generated L-LPS-specific mouse monoclonal antibodies (MAbs) and investigated if these MAbs can protect guinea pigs against fatal pulmonary hemorrhages caused by serovar Copenhageni. The MAbs L8H4 and L9B11 against 22 kDa L-LPS agglutinated leptospires and completely protected guinea pigs from the development of fatal pulmonary hemorrhages by serovar Copenhageni, whereas the MAb L4C1 against 8 kDa L-LPS neither agglutinated the bacteria nor protected the animals against the fatal pulmonary hemorrhages
机译：钩端螺旋体血清型哥本哈根菌引起呼吸道衰竭的肺出血，是钩端螺旋体病患者死亡的主要原因。已知对钩端螺旋体的保护性免疫与钩端螺旋体脂多糖（L-LPS）特异性凝集抗体的产生有关。我们生成了L-LPS特异性小鼠单克隆抗体（MAbs），并研究了这些MAb是否可以保护豚鼠免受血清哥本哈根虫引起的致命性肺出血。抗22 kDa L-LPS的钩端螺旋体的单克隆抗体L8H4和L9B11完全保护豚鼠免受血清型哥本哈根病毒致死性肺出血的发展，而抗8 kDa L-LPS的MAb L4C1既不凝集细菌也不保护动物免于致命肺出血

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