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首页> 外文期刊>Vaccine >A protein-based pneumococcal vaccine protects rhesus macaques from pneumonia after experimental infection with Streptococcus pneumoniae .
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A protein-based pneumococcal vaccine protects rhesus macaques from pneumonia after experimental infection with Streptococcus pneumoniae .

机译：实验性感染肺炎链球菌后，一种基于蛋白质的肺炎球菌疫苗可保护猕猴免受肺炎的侵袭。

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摘要

Infections caused by Streptococcus pneumoniae are a major cause of mortality throughout the world. Protein-based pneumococcal vaccines are envisaged to replace or complement the current polysaccharide-based vaccines. In this context, detoxified pneumolysin (dPly) and pneumococcal histidine triad protein D (PhtD) are two potential candidates for incorporation into pneumococcal vaccines. In this study, the protective efficacy of a PhtD-dPly vaccine was evaluated in a rhesus macaque (Macaca mulatta) model of pneumonia. The animals were immunized twice with 10 micro g of PhtD and 10 micro g of dPly formulated in the Adjuvant System AS02 or with AS02 alone, before they were challenged with a 19F pneumococcal strain. The survival was significantly higher in the protein-vaccinated group and seemed to be linked to the capacity to greatly reduce bacterial load within the first week post-challenge. Vaccination elicited high concentrations of anti-PhtD and anti-Ply antibodies and a link was found between survival and antibody levels. In conclusion, AS02-adjuvanted PhtD-dPly vaccine protects against S. pneumoniae-induced pneumonia. It is probable that the protection is at least partially mediated by PhtD- and Ply-specific antibodies.
机译：肺炎链球菌引起的感染是全世界死亡的主要原因。设想基于蛋白质的肺炎球菌疫苗来替代或补充当前基于多糖的疫苗。在这种情况下，解毒的肺炎球菌溶血素（dPly）和肺炎球菌组氨酸三联体蛋白D（PhtD）是掺入肺炎球菌疫苗的两个潜在候选者。在这项研究中，对PhtD-dPly疫苗的保护功效在恒河猴（肺炎猕猴）肺炎模型中进行了评估。在用19F肺炎球菌菌株攻击动物之前，用佐剂系统AS02或单独使用AS02配制的10微克PhtD和10微克dPly免疫动物两次。蛋白质疫苗接种组的存活率显着更高，并且似乎与在攻击后第一周内大大减少细菌负荷的能力有关。疫苗接种引起高浓度的抗PhtD和抗Ply抗体，并且在存活率和抗体水平之间发现了联系。总之，AS02辅助的PhtD-dPly疫苗可预防S。肺炎引起的肺炎。保护可能至少部分由PhtD和Ply特异性抗体介导。

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