Protection of European domestic pigs from virulent African isolates of African swine fever virus by experimental immunisation

King Katherine; Chapman Dave; Argilaguet Jordi M.; Fishbourne Emma; Hutet Evelyne; Cariolet Roland; Hutchings Geoff; Oura Christopher A. L.; Netherton Christopher L.; Moffat Katy; Taylor Geraldine; Le Potier Marie-Frederique; Dixon Linda K.; Takamatsu Haru-H Author; E-mail: haru.takamatsu@bbsrc.ac.uk.

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Protection of European domestic pigs from virulent African isolates of African swine fever virus by experimental immunisation

机译：通过实验免疫保护欧洲家猪免受非洲猪瘟病毒的强毒非洲分离株的侵害

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African swine fever (ASF) is an acute haemorrhagic disease of domestic pigs for which there is currently no vaccine. We showed that experimental immunisation of pigs with the non-virulent OURT88/3 genotype I isolate from Portugal followed by the closely related virulent OURT88/1 genotype I isolate could confer protection against challenge with virulent isolates from Africa including the genotype I Benin 97/1 isolate and genotype X Uganda 1965 isolate. This immunisation strategy protected most pigs challenged with either Benin or Uganda from both disease and viraemia. Cross-protection was correlated with the ability of different ASFV isolates to stimulate immune lymphocytes from the OURT88/3 and OURT88/1 immunised pigs

机译：非洲猪瘟（ASF）是家猪的急性出血性疾病，目前尚无疫苗。我们表明，对来自葡萄牙的非毒性OURT88 / 3基因型I分离株进行实验性免疫，然后对紧密相关的有毒力的OURT88 / 1基因型I分离株进行免疫接种，可以保护非洲免受包括I基因型贝宁97/1的强毒分离株的攻击分离株和基因型X乌干达1965年分离株。这种免疫策略可以保护大多数受到贝宁或乌干达攻击的猪免受疾病和病毒血症的侵害。交叉保护与不同ASFV分离株刺激OURT88 / 3和OURT88 / 1免疫猪的免疫淋巴细胞的能力相关

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《Vaccine》 |2011年第28期|共8页
作者
King Katherine; Chapman Dave; Argilaguet Jordi M.; Fishbourne Emma; Hutet Evelyne; Cariolet Roland; Hutchings Geoff; Oura Christopher A. L.; Netherton Christopher L.; Moffat Katy; Taylor Geraldine; Le Potier Marie-Frederique; Dixon Linda K.; Takamatsu Haru-H Author; E-mail: haru.takamatsu@bbsrc.ac.uk.;
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African swine fever viral vaccine: immunologic-drug; immunostimulant-drug; vaccine; pharmacodynamics;

机译：非洲猪瘟病毒疫苗：免疫药;免疫刺激剂;疫苗;药效学;

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1. Protection of European domestic pigs from virulent African isolates of African swine fever virus by experimental immunisation [J] . King Katherine, Chapman Dave, Argilaguet Jordi M., Vaccine . 2011,第28期

机译：通过实验免疫保护欧洲家猪免受非洲猪瘟病毒的强毒非洲分离株的侵害
2. Evaluation of protection induced by immunisation of domestic pigs with deletion mutant African swine fever virus BeninΔMGF by different doses and routes [J] . Pedro J. Sánchez-Cordón, Tamara Jabbar, Margot Berrezaie, Vaccine . 2018,第5期

机译：用不同剂量和途径免疫突变型非洲猪瘟病病毒Beninδmgf诱导的保护诱导的保护
3. Different routes and doses influence protection in pigs immunised with the naturally attenuated African swine fever virus isolate OURT88/3 [J] . Sanchez-Cordon Pedro J., Chapman Dave, Jabbar Tamara, Antiviral Research . 2017,第期

机译：不同的途径和剂量影响猪免疫的猪免疫，天然减毒的非洲猪瘟病毒分离OUT88 / 3
4. SEROLOGICAL TESTING OF THE SOUTH AFRICAN PIG HERD FOR EVIDENCE OF EXPOSURE TO EXOTIC VIRUSES AND AFRICAN SWINE FEVER [C] . J.T.R Robinson, R. Williams, M.L. Penrith Congress of the International Pig Veterinary Society . 2000

机译：南非猪群的血清学检测，用于接触异国病毒和非洲猪瘟的证据
5. Dynamics of protection against virulent challenge in swine vaccinated with attenuated African swine fever viruses. [D] . Carlson, Jolene Christine. 2016

机译：接种减毒非洲猪瘟病毒的猪对强毒攻击的保护动态。
6. Evaluation of protection induced by immunisation of domestic pigs with deletion mutant African swine fever virus BeninΔMGF by different doses and routes [O] . Pedro J. Sánchez-Cordón, Tamara Jabbar, Margot Berrezaie, -1

机译：不同剂量和途径用缺失突变型非洲猪瘟病毒贝宁ΔMGF免疫家猪的保护性评价
7. Protection of European domestic pigs from virulent African isolates of African swine fever virus by experimental immunisation [O] . King, Katherine, Chapman, Dave, Argilaguet, Jordi M., 2011

机译：通过实验免疫保护欧洲家猪免受非洲猪瘟病毒的强毒非洲分离株的侵害

Protection of European domestic pigs from virulent African isolates of African swine fever virus by experimental immunisation

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