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首页> 外文期刊>Vaccine >Dynamics of Streptococcus pneumoniae nasopharyngeal carriage with high heptavalent pneumococcal conjugate vaccine coverage in Central Greece.
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Dynamics of Streptococcus pneumoniae nasopharyngeal carriage with high heptavalent pneumococcal conjugate vaccine coverage in Central Greece.

机译：在希腊中部具有高七价肺炎球菌结合疫苗覆盖率的肺炎链球菌鼻咽运输的动力学。

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摘要

In order to study whether the use of the heptavalent pneumococcal conjugate vaccine (PCV7) led to a shift in the Streptococcus pneumoniae serotypes distribution and whether it modified the resistance to antibiotics, 2649 nasopharyngeal samples were obtained between 2005 and 2009, from children attending day-care centers in Central Greece. The percentage of attendees vaccinated with >=1 dose of PCV7 increased from 12.9% (2005) to 95.5% (2009). Non-PCV7 serotypes replaced those belonging to PCV7. In 2009, 19F was virtually the only PCV7 serotype that continued to circulate. A significant increase in the frequency of penicillin-intermediate (oral penicillin V breakpoints) isolates coincided with a marked reduction in isolates with high resistance to penicillin. Several non-PCV7 serotypes colonized the children, but their frequency varied substantially from year to year. Each one of 14 specific non-PCV7 serotypes, i.e. 6A, 11A, 15B, 23A, 10A, 16F, 38, 22F, 15C, 19A, 35F, 24F, 6C, and 7F, accounted for >=2% of pneumococcal isolates in at least 2 annual surveillances. An increase in non-PCV7 serotypes with antibiotic resistance, beyond 6A and 19A, occurred. Intermediate resistance to penicillin was observed in serotype 23B, 15B, 15C, 15A, 35F, 6C, and 24F pneumococci. Their exact role in invasive and non-invasive disease remains to be seen in the years ahead. Copyright Copyright 2011 Elsevier Ltd. All rights reserved.
机译：为了研究是否使用七价肺炎球菌结合疫苗（PCV7）导致了肺炎链球菌血清型分布的改变，以及它是否改变了对抗生素的耐药性，2005年至2009年间，从第2天就读的儿童中获得了2649份鼻咽样本。希腊中部的医疗中心。 ≥1剂PCV7疫苗接种的参与者比例从12.9％（2005）增加到95.5％（2009）。非PCV7血清型取代了属于PCV7的血清型。在2009年，19F实际上是唯一继续传播的PCV7血清型。青霉素中间体（口服青霉素V断裂点）的频率显着增加，同时对青霉素具有高抗性的菌株明显减少。几种非PCV7血清型定植在儿童中，但是它们的频率逐年变化很大。 14种特定的非PCV7血清型中的每一种，即6A，11A，15B，23A，10A，16F，38、22F，15C，19A，35F，24F，6C和7F，均占肺炎球菌分离株的> = 2％至少2次年度监视。耐药性超过6A和19A的非PCV7血清型增加。在血清型23B，15B，15C，15A，35F，6C和24F肺炎球菌中观察到了对青霉素的中等耐药性。它们在侵袭性和非侵袭性疾病中的确切作用仍有待观察。版权版权所有2011 ElsevierLtd。保留所有权利。

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