...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Vaccine >A novel retinoic acid, catechin hydrate and mustard oil-based emulsion for enhanced cytokine and antibody responses against multiple strains of HIV-1 following mucosal and systemic vaccinations
【24h】

A novel retinoic acid, catechin hydrate and mustard oil-based emulsion for enhanced cytokine and antibody responses against multiple strains of HIV-1 following mucosal and systemic vaccinations

机译：一种新颖的视黄酸，儿茶素水合物和芥菜油基乳剂，可在粘膜和全身疫苗接种后增强针对多种HIV-1菌株的细胞因子和抗体反应

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Non-replicating protein- or DNA-based antigens generally require immune-enhancing adjuvants and delivery systems. It has been particularly difficult to raise antibodies against gp120 of HIV-1, which constitutes an important approach in HIV vaccine design. While almost all effort in adjuvant research has focused on mimicking the pathogens and the danger signals they engender in the host, relatively little effort has been spent on nutritive approaches. In this study, a new nutritive immune-enhancing delivery system (NIDS) composed of vitamin A, a polyphenol-flavonoid, catechin hydrate, and mustard oil was tested for its adjuvant effect in immune responses against the gp120 protein of HIV-1(CN54). Following a combination of two mucosal and two systemic vaccinations of mice, we found significant enhancement of both local and systemic antibodies as well as cytokine responses. These data have important implications for vaccine and adjuvant design against HIV-1 and other pathogens
机译：非复制性基于蛋白质或DNA的抗原通常需要增强免疫的佐剂和递送系统。产生针对HIV-1 gp120的抗体特别困难，这构成了HIV疫苗设计的重要方法。尽管辅助研究中几乎所有的努力都集中在模仿病原体及其在宿主中产生的危险信号，但在营养方法上的投入却相对较少。在这项研究中，测试了一种由维生素A，多酚类黄酮，儿茶素水合物和芥末油组成的新型营养免疫增强递送系统（NIDS）对HIV-1（CN54）gp120蛋白的免疫应答的辅助作用）。小鼠的两次粘膜和两次全身接种后，我们发现局部和全身抗体以及细胞因子应答均显着增强。这些数据对于针对HIV-1和其他病原体的疫苗和佐剂设计具有重要意义

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号