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Multigenic control of measles vaccine immunity mediated by polymorphisms in measles receptor, innate pathway, and cytokine genes

机译：麻疹受体，先天途径和细胞因子基因多态性介导的麻疹疫苗免疫的多基因控制

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摘要

Measles infection and vaccine response are complex biological processes that involve both viral and host genetic factors. We have previously investigated the influence of genetic polymorphisms on vaccine immune response, including measles vaccines, and have shown that polymorphisms in HLA, cytokine, cytokine receptor, and innate immune response genes are associated with variation in vaccine response but do not account for all of the inter-individual variance seen in vaccinated populations. In the current study we report the findings of a multigenic analysis of measles vaccine immunity, indicating a role for the measles virus receptor CD46, innate pattern-recognition receptors (DDX58, TLR2, 4, 5, 7 and 8) and intracellular signaling intermediates (MAP3K7, NFKBIA), and key antiviral molecules (VISA, OAS2, MX1, PKR) as well as cytokines (IFNA1, IL4, IL6, IL8, IL12B) and cytokine receptor genes (IL2RB, IL6R, IL8RA) in the genetic control of both humoral and cellular immune responses. This multivariate approach provided additional insights into the genetic control of measles vaccine responses over and above the information gained by our previous univariate SNP association analyses
机译：麻疹感染和疫苗反应是复杂的生物学过程，涉及病毒和宿主遗传因素。我们之前已经研究了遗传多态性对疫苗免疫应答（包括麻疹疫苗）的影响，并表明HLA，细胞因子，细胞因子受体和先天性免疫应答基因中的多态性与疫苗应答中的变异相关，但不能解释所有的原因。接种人群中个体间差异。在本研究中，我们报告了对麻疹疫苗免疫性的多基因分析结果，表明麻疹病毒受体CD46，先天性模式识别受体（DDX58，TLR2、4、5、7和8）和细胞内信号传导中间体（ MAP3K7，NFKBIA）和关键抗病毒分子（VISA，OAS2，MX1，PKR）以及细胞因子（IFNA1，IL4，IL6，IL8，IL12B）和细胞因子受体基因（IL2RB，IL6R，IL8RA）体液和细胞免疫反应。除了我们以前的单变量SNP关联分析所获得的信息之外，这种多变量方法还为麻疹疫苗反应的遗传控制提供了更多见解。

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