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首页> 外文期刊>Vaccine >Mumps vaccine effectiveness in primary schools and households, the Netherlands, 2008
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Mumps vaccine effectiveness in primary schools and households, the Netherlands, 2008

机译：2008年荷兰腮腺炎疫苗在小学和家庭中的有效性

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摘要

To estimate the mumps vaccine effectiveness (VE) during a large genotype D mumps outbreak, we conducted a cross-sectional study in eight primary schools and associated households in the Netherlands. Questionnaires were used to collect information on the occurrence of mumps. Multivariate analyses were used to estimate VE. Among schoolchildren we estimated the VE against mumps. Among household contacts where the schoolchild was the index case we estimated the VE against mumps and against mumps infectiousness. In total 1175 children and 2281 household contacts participated in the study. The mumps attack rate among schoolchildren was 17%. The mumps VE in schoolchildren was 92% [95% confidence interval (CI) 83-96%] and 93% [85-97%] for one and two doses of the measles, mumps, rubella (MMR) vaccine, respectively. The adjusted mumps VE among household contacts was 67% [65-95%] and 11% [-4 to 88%] against mumps and mumps infectiousness, respectively. Our study indicates that the mumps component of the MMR vaccine offered adequate protection against mumps among schoolchildren. The relatively low VE among household contacts is of concern. (C) 2012 Elsevier Ltd. All rights reserved.
机译：为了估计大基因型D型腮腺炎暴发期间的腮腺炎疫苗有效性（VE），我们在荷兰的8所小学和相关家庭中进行了横断面研究。问卷被用来收集有关腮腺炎发生的信息。多变量分析用于估计VE。在学童中，我们估计了针对腮腺炎的VE。在以小学生为指标的家庭接触者中，我们估计了针对腮腺炎和腮腺炎传染性的VE。共有1175名儿童和2281位家庭成员参加了这项研究。小学生的腮腺炎发作率为17％。一剂和两剂麻疹，腮腺炎，风疹（MMR）疫苗的学龄儿童腮腺炎VE分别为92％[95％置信区间（CI）83-96％]和93％[85-97％]。家庭接触者经调整的腮腺炎VE对腮腺炎和腮腺炎的传染性分别为67％[65-95％]和11％[-4至88％]。我们的研究表明，MMR疫苗的腮腺炎成分为学龄儿童的腮腺炎提供了充分的保护。家庭接触者中相对较低的VE值得关注。 （C）2012 Elsevier Ltd.保留所有权利。

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