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History of meningococcal vaccines and their serological correlates of protection

机译：脑膜炎球菌疫苗的历史及其保护的血清学相关性

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For over a hundred years Neisseria meningitidis has been known to be one of the major causes of bacterial meningitis. However, effective vaccines were not developed until the latter part of the 20th century. The first of these were based on purified high molecular weight capsular polysaccharides and more recently the development of glycoconjugate vaccines has made paediatric immunisation programmes possible. The prevention of group B meningococcal disease has remained a challenge throughout this period. This review charts the history of the development of meningococcal vaccines and the importance of serological correlates of protection in their evaluation. (C) 2012 Elsevier Ltd. All rights reserved.
机译：一百多年来，脑膜炎​​奈瑟氏球菌是细菌性脑膜炎的主要原因之一。但是，直到20世纪后期才开发出有效的疫苗。这些中的第一个是基于纯化的高分子量荚膜多糖，最近，糖缀合物疫苗的开发使儿科免疫计划成为可能。在此期间，预防B组脑膜炎球菌疾病一直是一项挑战。这篇综述总结了脑膜炎球菌疫苗的发展历史以及评估中血清学相关因素的重要性。 （C）2012 Elsevier Ltd.保留所有权利。

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