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Combined protective effects of anti-PhtD and anti-pneumococcal polysaccharides

机译:抗PhtD和抗肺炎球菌多糖的联合保护作用

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摘要

In the past years, a significant rise in the proportion of childhood complicated pneumonia cases related to pneumococcal serotypes 1 and 3 has been observed. PhtD is a vaccine candidate protein antigen. By using a pneumococcal lethal intranasal challenge mouse model, a significant additive effect on protection was observed with the combination of vaccination-induced anti-PhtD and injected anti-polysaccharide antibodies specific for serotypes 1 and 3
机译:在过去的几年中,已经观察到与肺炎球菌血清型1和3相关的儿童期复杂性肺炎病例的比例显着上升。 PhtD是疫苗候选蛋白抗原。通过使用肺炎球菌致死性鼻内攻击小鼠模型,结合接种疫苗诱导的抗PhtD和注射的针对血清型1和3的抗多糖抗体,观察到了对保护作用的显着累加作用

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