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首页> 外文期刊>Vaccine >Effectiveness of Vi capsular polysaccharide typhoid vaccine among children: a cluster randomized trial in Karachi, Pakistan.
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Effectiveness of Vi capsular polysaccharide typhoid vaccine among children: a cluster randomized trial in Karachi, Pakistan.

机译：儿童荚膜多糖伤寒疫苗的有效性：在巴基斯坦卡拉奇进行的一项集群随机试验。

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Background: Typhoid fever is endemic in Karachi, with an incidence among children ranging from 170 to 450 per 100,000 child-years. Vaccination strategies are important for prevention, and the Vi capsular polysaccharide (ViCPS) vaccine has been shown to be effective in reducing the burden of typhoid fever. Methods: A cluster randomized trial was conducted in three low socioeconomic urban squatter settlements in Karachi, Pakistan between 2002 and 2007. Subsamples were followed up for assessment of immune response and adverse events after vaccination. Results: The study participants were similar in a wide variety of socio-demographic and economic characteristics at baseline. A total of 27,231 individuals of the total target population of 51,965 in 120 clusters either received a ViCPS vaccine (13,238 [52% coverage]) or the control Hepatitis A vaccine (13,993 [53%]). Typhoid fever was diagnosed in 30 ViCPS vaccine recipients and 49 Hepatitis A vaccine recipients with an adjusted total protective effectiveness of 31% (95%CI: -28%, 63%). The adjusted total vaccine protective effectiveness was -38% (95%CI: -192%, 35%) for children aged 2-5 years and 57% (95%CI: 6%, 81%) for children 5-16 years old. Conclusion: The ViCPS vaccine did not confer statistically significant protection to children in the study areas, and there was a decline in antibody response 2 years post-vaccination. However, the ViCPS vaccine showed significant total protection in children 5-16 years of age, which is consistent with other studies of ViCPS vaccine conducted in India, Nepal, China and South Africa. These findings suggest that ViCPS vaccination of school-aged children will protect the children of urban, typhoid endemic areas against typhoid fever.
机译：背景：伤寒在卡拉奇流行，在儿童中的发病率为每10万儿童年170至450。疫苗接种策略对于预防很重要，Vi荚膜多糖（ViCPS）疫苗已证明可有效减轻伤寒负担。方法：2002年至2007年间，在巴基斯坦卡拉奇的三个低社会经济地位的城市屋居民区进行了一项整群随机试验。对子样本进行随访，以评估接种疫苗后的免疫反应和不良事件。结果：研究参与者在基线时的各种社会人口统计学和经济特征方面相似。在120个群中，共有51,965名目标人群中的27,231名个体接受了ViCPS疫苗（13,238 [覆盖率52％]）或对照A型肝炎疫苗（13,993 [53％]）。在30例ViCPS疫苗接种者和49例A型肝炎疫苗接种者中诊断出伤寒，调整后的总保护效果为31％（95％CI：-28％，63％）。调整后的2-5岁儿童总疫苗保护有效性为-38％（95％CI：-192％，35％）和5-16岁儿童为57％（95％CI：6％，81％） 。结论：ViCPS疫苗并未为研究区域的儿童提供统计学上的显着保护，并且接种疫苗后2年抗体反应下降。但是，ViCPS疫苗对5-16岁的儿童显示出明显的全面保护作用，这与在印度，尼泊尔，中国和南非进行的其他ViCPS疫苗研究一致。这些发现表明，对学龄儿童进行的ViCPS疫苗接种将保护市区伤寒流行地区的儿童免于伤寒。

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