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首页> 外文期刊>Vaccine >Reduced antibody responses against Plasmodium falciparum vaccine candidate antigens in the presence of Trichuris trichiura.
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Reduced antibody responses against Plasmodium falciparum vaccine candidate antigens in the presence of Trichuris trichiura.

机译：在Trichuris trichiura存在下，针对恶性疟原虫疫苗候选抗原的抗体反应降低。

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摘要

Background: Helminth infections are highly prevalent in the tropics and may have an effect on immune responses to vaccines due to their immunomodulatory effect. The prevalence of helminth infections in young children, the target group for malaria and most other vaccines, is high. Therefore we assessed the influence of helminth infection on vaccine-induced immune responses in a phase I clinical trial of the malaria vaccine candidate GMZ2. Methods: Twenty Gabonese preschool-age children were vaccinated with GMZ2, a blood stage malaria vaccine candidate. Humoral immune response against the vaccine antigens and parasitological status were assessed. Vaccine-specific antibody concentrations and memory B-cell numbers were compared in worm infected and non-infected participants. Results: Antibody response to GMZ2 was 3.4-fold (95% confidence interval: 1.6, 7.4) higher in Trichuris trichiura negative subjects compared to positive participants, whereas immunoglobulin subclass distribution was similar. Memory B-cell response was moderately increased in T. trichiura negative individuals, although the difference was not significant. Conclusions: Future malaria vaccine development programs need to account for worm-mediated hyporesponsiveness of immune reactions.
机译：背景：蠕虫感染在热带地区非常普遍，由于其免疫调节作用，可能会对疫苗的免疫反应产生影响。幼儿（疟疾和大多数其他疫苗的目标群体）的蠕虫感染率很高。因此，我们在疟疾候选疫苗GMZ2的I期临床试验中评估了蠕虫感染对疫苗诱导的免疫反应的影响。方法：20名加蓬学龄前儿童接种了GMZ2疫苗，这是一种血液疟疾候选疫苗。评估了针对疫苗抗原的体液免疫反应和寄生虫学状况。比较了蠕虫感染和未感染参与者的疫苗特异性抗体浓度和记忆B细胞数量。结果：Trichuris trichiura阴性受试者对GMZ2的抗体应答比阳性受试者高3.4倍（95％置信区间：1.6、7.4），而免疫球蛋白亚类分布相似。 T. trichiura阴性个体的记忆B细胞反应适度增加，尽管差异不显着。结论：未来的疟疾疫苗开发计划需要考虑蠕虫介导的免疫反应的低反应性。

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