A VaxfectinReg.-adjuvanted HSV-2 plasmid DNA vaccine is effective for prophylactic and therapeutic use in the guinea pig model of genital herpes.

Veselenak R. L.; Shlapobersky M.; Pyles R. B.; Wei Q.; Sullivan S. M.; Bourne N.

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A VaxfectinReg.-adjuvanted HSV-2 plasmid DNA vaccine is effective for prophylactic and therapeutic use in the guinea pig model of genital herpes.

机译：VaxfectinReg。佐剂的HSV-2质粒DNA疫苗可有效地在生殖器疱疹的豚鼠模型中进行预防和治疗。

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Here we describe studies in the guinea pig model of genital herpes to evaluate a novel plasmid DNA (pDNA) vaccine encoding the HSV-2 glycoprotein D and UL46 and UL47 genes encoding tegument proteins VP11/12 and VP 13/14 (gD2/UL46/UL47), formulated with a cationic lipid-based adjuvant VaxfectinReg.. Prophylactic immunization with VaxfectinReg.-gD2/UL46/UL47 significantly reduced viral replication in the genital tract, provided complete protection against both primary and recurrent genital skin disease following intravaginal HSV-2 challenge, and significantly reduced latent HSV-2 DNA in the dorsal root ganglia compared to controls. We also examined the impact of therapeutic immunization of HSV-2 infected animals. Here, VaxfectinReg.-gD2/UL46/UL47 immunization significantly reduced both the frequency of recurrent disease and viral shedding into the genital tract compared to controls. This novel adjuvanted pDNA vaccine has demonstrated both prophylactic and therapeutic efficacy in the guinea pig model of genital herpes and warrants further development.

机译：在这里，我们描述了生殖器疱疹豚鼠模型中的研究，以评估编码HSV-2糖蛋白D和UL46的新型质粒DNA（pDNA）疫苗以及编码外皮蛋白VP11 / 12和VP 13/14（gD2 / UL46 / UL47），以阳离子脂质为基础的佐剂VaxfectinReg。配制而成。用VaxfectinReg.-gD2 / UL46 / UL47进行的预防性免疫可显着减少生殖道中的病毒复制，为阴道内HSV-2引起的原发性和复发性生殖器皮肤病提供了全面的保护。挑战，并与对照组相比，显着降低了背根神经节中的潜在HSV-2 DNA。我们还检查了HSV-2感染动物治疗性免疫的影响。在此，与对照相比，VaxfectinReg.-gD2 / UL46 / UL47免疫显着降低了复发性疾病的频率和病毒进入生殖道的频率。这种新颖的佐剂pDNA疫苗在生殖器疱疹的豚鼠模型中已显示出预防和治疗功效，并有待进一步开发。

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《Vaccine》 |2012年第49期|共6页
作者
Veselenak R. L.; Shlapobersky M.; Pyles R. B.; Wei Q.; Sullivan S. M.; Bourne N.;
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正文语种 eng
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animal models; disease models; DNA vaccines; glycoproteins; herpes simplex genitalis; immunization; laboratory animals; plasmids; vaccination; vaccines; guineapigs; Human herpesvirus 2; Cavia; Caviidae; rodents; mammals; vertebrates; Chordata; animals; eukaryotes; Simplexvirus; Alphaherpesvirinae; Herpesviridae; Herpesvirales; dsDNA Viruses; DNA Viruses; viruses; guinea pigs; immune sensitization;

机译：动物模型;疾病模型;DNA疫苗;糖蛋白;生殖器疱疹;免疫;实验室动物;质粒;疫苗;疫苗;豚鼠;人疱疹病毒2;Cavia;甲鱼科;啮齿动物;哺乳动物;脊椎动物;Chordata;动物;真核生物;Simplex Alphaherpesvirinae;Herpesviridae;Herpesvirales;dsDNA病毒;DNA病毒;病毒;豚鼠;免疫致敏;

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1. A VaxfectinReg.-adjuvanted HSV-2 plasmid DNA vaccine is effective for prophylactic and therapeutic use in the guinea pig model of genital herpes. [J] . Veselenak R. L., Shlapobersky M., Pyles R. B., Vaccine . 2012,第49期

机译：VaxfectinReg。佐剂的HSV-2质粒DNA疫苗可有效地在生殖器疱疹的豚鼠模型中进行预防和治疗。
2. The HSV-1 live attenuated VC2 vaccine provides protection against HSV-2 genital infection in the guinea pig model of genital herpes [J] . Bernstein David I, Pullum Derek A., Cardin Rhonda D., Vaccine . 2019,第1期

机译：HSV-1活病变VC2疫苗提供了在生殖器疱疹的豚鼠模型中对HSV-2生殖器感染的保护
3. The R2 non-neuroinvasive HSV-1 vaccine affords protection from genital HSV-2 infections in a guinea pig model [J] . David I. Bernstein, Rhonda D. Cardin, Gregory A. Smith, NPJ vaccines. . 2020,第1期

机译：R2非神经侵袭性HSV-1疫苗提供了豚鼠模型中的生殖器HSV-2感染的保护
4. Clinical Development of Formulated Therapeutic and Prophylactic DNA-based Vaccines - (PPT) [C] . Alain Rolland Vaccine Technology Symposium . 2010

机译：配方治疗和预防性DNA疫苗的临床发展 - （PPT）
5. Plasmid DNA as a Platform for the Development of Prophylactic and Therapeutic Vaccines Against Clostridium difficile in Aging Models of Disease [D] . Ramamurthi, Arjun 2017

机译：质粒DNA作为在疾病老龄化模型中开发针对艰难梭菌的预防和治疗疫苗的平台
6. A Vaxfectin®-adjuvanted HSV-2 plasmid DNA vaccine is effective for prophylactic and therapeutic use in the guinea pig model of genital herpes [O] . Ron L. Veselenak, Mark Shlapobersky, Richard B. Pyles, -1

机译：vaxfectin®-佐剂的HSV-2质粒DNA疫苗对于在生殖器疱疹的豚鼠模型中是有效的预防和治疗用途
7. A Vaxfectin®-adjuvanted HSV-2 plasmid DNA vaccine is effective for prophylactic and therapeutic use in the guinea pig model of genital herpes [O] . Ronald L. Veselenak, Mark Shlapobersky, Richard B. Pyles, 2012

机译：vaxfectin®-佐剂的HSV-2质粒DNA疫苗对于在生殖器疱疹的豚鼠模型中是有效的预防和治疗用途
8. Use of a Guinea Pig-Specific Transcriptome Array for Evaluation of Protective Immunity against Genital Chlamydial Infection following Intranasal Vaccination in Guinea Pigs. [R] . Wali, S., Gupta, R., Veselenak, R. L., 2014

机译：使用豚鼠特异性转录组阵列评估豚鼠鼻内接种后生殖器衣原体感染的保护性免疫。

A VaxfectinReg.-adjuvanted HSV-2 plasmid DNA vaccine is effective for prophylactic and therapeutic use in the guinea pig model of genital herpes.

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