Nanovaccinology: The next generation of vaccines meets 21st century materials science and engineering

Mamo Tewodros; Poland Gregory A.

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Nanovaccinology: The next generation of vaccines meets 21st century materials science and engineering

机译：纳米疫苗学：下一代疫苗符合21世纪材料科学与工程

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After a century of empirical vaccine development focused on the “isolate-inactivate-inject” paradigm, vaccinology is moving toward directed development and the rational design of new candidate vaccines [1]. An important direction for vaccinology is that future vaccines may no longer contain live or inactivated whole pathogens. The pneumococcal, meningococcal and Hib polysaccharide conjugate vaccines, the HBV recombinant subunit vaccine and the HPV VLP vaccines are prime examples of new generations of vaccines whose immunogenicity is focused on specific antigenic epitopes. Such subunit vaccines are highly immunogenic, safe, and easier to produce than live whole pathogen biologic products.

机译：经过一个世纪的经验疫苗开发，重点是“分离-灭活-注射”范式，疫苗学正朝着定向开发和新候选疫苗的合理设计方向发展[1]。疫苗学的重要方向是未来的疫苗可能不再包含活的或灭活的完整病原体。肺炎球菌，脑膜炎球菌和Hib多糖结合疫苗，HBV重组亚单位疫苗和HPV VLP疫苗是新一代疫苗的主要例子，其免疫原性集中在特定的抗原表位上。此类亚单位疫苗比全病原体生物制品具有更高的免疫原性，安全性和生产性。

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《Vaccine》 |2012年第47期|共3页
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Mamo Tewodros; Poland Gregory A.;
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1. Nanovaccinology: The next generation of vaccines meets 21st century materials science and engineering [J] . Mamo Tewodros, Poland Gregory A. Vaccine . 2012,第47期

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Nanovaccinology: The next generation of vaccines meets 21st century materials science and engineering

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