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首页> 外文期刊>Vaccine >Vaccine effectiveness in preventing influenza hospitalizations in Navarre, Spain, 2010-2011: Cohort and case-control study
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Vaccine effectiveness in preventing influenza hospitalizations in Navarre, Spain, 2010-2011: Cohort and case-control study

机译：2010-2011年西班牙纳瓦拉预防流感住院的疫苗有效性：队列和病例对照研究

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摘要

We evaluated the 2010-2011 seasonal influenza vaccine effectiveness in preventing hospitalizations. Using healthcare databases we defined the target population for vaccination in Navarre, Spain, consisting of 217,320 people with major chronic conditions or aged 60 years and older. All hospitalized patients with influenza-like illness (ILI) were swabbed for influenza testing. A total of 269 patients with ILI were hospitalized and 61 of them were found positive for influenza virus: 58 for A(HIN1)2009 and 3 for B virus. The incidence rates of hospitalization with laboratory-confirmed influenza were compared by vaccination status. In the Cox regression model adjusted for sex, age, children in the household, urban/rural residence, comorbidity, pandemic vaccination, pneumococcal vaccination, outpatient visits and hospitalization in the previous year, the seasonal vaccine effectiveness was 58% (95% CI: 16-79%). The nested test-negative case-control analysis gave an adjusted estimate of 59% (95% CI: 4-83%). These results suggest a moderate effect of the 2010-2011 seasonal influenza vaccine in preventing hospitalization in a risk population. The close estimates obtained in the cohort and the test-negative case-control analyses suggest good control of biases. (C) 2011 Elsevier Ltd. All rights reserved.
机译：我们评估了2010-2011年季节性流感疫苗在预防住院方面的有效性。使用医疗保健数据库，我们定义了西班牙纳瓦拉的疫苗接种目标人群，其中包括217,320名患有严重慢性病或60岁以上的人。所有住院的流感样疾病（ILI）患者均被擦拭以进行流感检测。总共269例ILI患者住院治疗，其中61例流感病毒呈阳性：A（HIN1）2009 58例，B病毒3例。通过疫苗接种状况比较了实验室确诊的流感住院的发生率。在针对性别，年龄，家庭儿童，城市/农村居民，合并症，大流行疫苗接种，肺炎球菌疫苗接种，门诊就诊和住院的前一年进行Cox回归模型调整后，季节性疫苗有效性为58％（95％CI： 16-79％）。巢式测试阴性病例对照分析得出的调整后估计值为59％（95％CI：4-83％）。这些结果表明，2010-2011年季节性流感疫苗在预防高危人群住院方面具有中等作用。在队列和测试阴性病例对照分析中获得的接近估计值表明对偏倚的良好控制。 （C）2011 Elsevier Ltd.保留所有权利。

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